P6.17 PATTERN BETWEEN ARTERIAL STIFFNESS, BLOOD PRESSURE AND AGE OBSERVED IN INDIVIDUAL PATIENTS AND REFERENCE POPULATION EXPLAINED BY BIOMECHANICS OF WALL REMODELLING
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- 10.1016/j.artres.2013.10.198How to use a DOI?
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Background: We recently found in patients that the pressure dependency of arterial stiffness is age-dependent, explaining clinically observed changes in stiffness with blood pressure (BP) lowering. Pulse wave velocity, BP and age found in the Reference Values for Arterial Stiffness Collaboration show a corresponding pattern. We hypothesised that the impact of age on the pressure-dependency of arterial stiffness actually reflects changes in wall constituent properties and adaptation to mechanical stress
Methods and results: We applied a constitutive model of arterial wall biomechanics (Zulliger, AJP-Heart 2004) to simulate ageing, based on detailed pressure-area curves obtained in our younger (mean age 40 yrs, n=6) and older (65 yrs, n=7) hypertensive patients. Ageing was simulated by adapting the model (initially fitted to the "young" pressure-area curve) to fit the "old" curve (Figure); allowing for elastin degradation, collagen rearrangement and wall thickness adaptation, but not for changes in fractional volumes. The simulation showed a physiologically significant transfer of pressure-load bearing from elastin to collagen, caused by a 40% loss in elastin stiffness and a 5-fold increase in collagen recruitment (Table). Presuming normalisation and homogeneous distribution of wall stress with ageing, the predicted increase in wall thickness was in accordance with intima-media thickness Reference Values (2010 data; 25-yr increment, corresponding risk category).
Conclusion: Ageing influences observed arterial stiffness values at given blood pressures through underlying changes in the properties and mechanical loading of arterial wall constituents.
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TY - JOUR AU - B. Spronck AU - M.H.G. Heusinkveld AU - A.A. Kroon AU - T. Delhaas AU - K.D. Reesink PY - 2013 DA - 2013/11/11 TI - P6.17 PATTERN BETWEEN ARTERIAL STIFFNESS, BLOOD PRESSURE AND AGE OBSERVED IN INDIVIDUAL PATIENTS AND REFERENCE POPULATION EXPLAINED BY BIOMECHANICS OF WALL REMODELLING JO - Artery Research SP - 158 EP - 159 VL - 7 IS - 3-4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2013.10.198 DO - 10.1016/j.artres.2013.10.198 ID - Spronck2013 ER -