P4.22 THE ROLE OF TESTOSTERONE AND ARTERIAL STIFFNESS IN THE PREDICTION OF RISK FOR CARDIOVASCULAR EVENTS IN HYPERTENSIVE PATIENTS

DOI

10.1016/j.artres.2013.10.140How to use a DOI?

Abstract

Objectives: Androgen deficiency confers an independent risk for cardiovascular events and total mortality. Hypertension, a major contributory factor to the development of cardiovascular disease (CVD), has been associated with increased prevalence of low testosterone. We investigated whether low androgen concentration predicts major adverse cardiovascular events (MACE) in hypertensive patients without clinical atherosclerosis.

Methods: MACE in relation to total testosterone (TT) were analyzed with proportional hazards models in 228 non-diabetic hypertensive patients without a history of known CVD.

Results: The mean follow-up time was 44 months, during which 19 (8.3%) subjects developed MACE. Compared to patients who did not experience MACE, subjects who developed MACE had lower TT (3.9±0.7 ng/ml vs 4.6±1.5 ng/ml; P<0.01) and higher PWV (9.5±1.4 vs 8.4±1.3 m/s; P<0.001). Kaplan–Meier survival curves for MACE by TT tertiles at baseline are shown in figure. Subjects in the lowest TT tertile (<4.0 ng/ml) had a statistically significant higher risk of MACE compared to those in the highest tertile (>4.9 ng/ml) in multivariate Cox models adjusted for age, systolic blood pressure and risk factors (all P<0.05). Addition of TT to standard risk factors model yielded a net reclassification improvement of 38.8% (P<0.05). In regression analysis, PWV was inversely associated with TT (β=−0.207, P<0.001), indicating deterioration of aortic stiffness with decreasing testosterone level.

Conclusions: The principal finding of our study is that androgen deficiency predicts independently MACE in long-term follow-up in hypertensive patients. The association of TT with aortic stiffness may suggest other mechanisms, such as changes in vascular function and structure.

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TY  - JOUR
AU  - N. Ioakeimidis
AU  - C. Vlachopoulos
AU  - D. Terentes-Printzios
AU  - A. Aggelis
AU  - M. Abdelasoul
AU  - I. Androutsos
AU  - P. Pietri
AU  - C. Stefanadis
PY  - 2013
DA  - 2013/11/11
TI  - P4.22 THE ROLE OF TESTOSTERONE AND ARTERIAL STIFFNESS IN THE PREDICTION OF RISK FOR CARDIOVASCULAR EVENTS IN HYPERTENSIVE PATIENTS
JO  - Artery Research
SP  - 141
EP  - 142
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.140
DO  - 10.1016/j.artres.2013.10.140
ID  - Ioakeimidis2013
ER  -