P3.32 THE NUMBER OF METABOLIC SYNDROME RISK FACTORS CORRELATES WITH AORTIC STIFFNESS
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- 10.1016/j.artres.2013.10.119How to use a DOI?
- Abstract
Objectives: Metabolic syndrome (MS) is a cluster of ≥3 risk factors (RF). The presence of subclinical organ damage increases the risk of cardiovascular disease in patients with MS. Arterial stiffness and wave reflections are independent predictors of cardiovascular disease. The aim of our study was to compare pulse wave velocity (PWV) and parameters of wave reflections in subjects with different number of MS risk factors (definition of MS according to Czech guidelines: arterial hypertension or antihypertensive drug treatment, waist circumference, serum triglycerides or lipid-lowering drug treatment, HDL cholesterol, type 2 diabetes mellitus or impaired glucose tolerance).
Methods: We examined 936 respondents from the Czech general population (post-MONICA study). We measured aortic PWV, augmentation index (AIx) and central augmentation pressure (cAP) using SphygmoCor device. We divided subjects into 5 groups according to number of RF (0,1,2,3, ≥4). We used multivariate linear regression analysis to assess association between the number of RF and PWV, AIx and cAP after adjustment for age, gender, heart rate and MAP.
Results: 334 respondents (35.7 %) had MS. Subjects with MS were older (60.4±9.8 years vs. 51.0±13.6 years, p<0.0001) and had higher PWV than subjects without MS (9.0±2.3 m/s vs. 7.3±2.1 m/s, p<0.0001). After adjustment for covariates, the PWV (pfor trend <0.0001), and cAP (p=0.025) were higher with increasing number of RF, while AIx was lower (p=0.020).
Conclusions: With growing number of metabolic syndrome risk factors, the aortic PWV and central augmentation pressure increase, while opposite is true for central augmentation index.
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TY - JOUR AU - Vágovičová Petra AU - Mlíková Seidlerová Jitka AU - Filipovský Jan AU - Mayer Otto AU - Wohlfahrt Peter AU - Cífková Renata PY - 2013 DA - 2013/11/11 TI - P3.32 THE NUMBER OF METABOLIC SYNDROME RISK FACTORS CORRELATES WITH AORTIC STIFFNESS JO - Artery Research SP - 135 EP - 135 VL - 7 IS - 3-4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2013.10.119 DO - 10.1016/j.artres.2013.10.119 ID - Petra2013 ER -