Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 132 - 132

P3.21 CENTRAL HEMODYNAMICS PARAMETERS IN BLACK HYPERTENSIVE PATIENTS BORN AND LIVING IN SUB-SAHARAN AFRICA

Authors
M.K. Kamdem1, E.A. Birinus2, D. Lemougoum1, B.C. Anisiuba2, J. Kaptue1, J. Staessen3, 4, M’buyamba Rene3, 5, A. Odili6
1Douala Cardiovascular Research Institute, Douala School of Medicine, Douala, Cameroon
2Department of Medicine, College of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria
3Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Di, leuven, Belgium
4Department of Epidemiology, Maastricht University, Maastricht, Netherlands
5Hypertension Unit, Department of Internal Medicine, University of Kinshasa Hospital, Kinshasa, The Democratic Republic of, kinshasa, Democratic Republic of the Congo
6Department of Internal Medicine, College of Health Science, University of Abuja, Abuja, Nigeria
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.108How to use a DOI?
Abstract

Background: Few studies assessed arterial stiffness in Black hypertensive patients Born and living in sub-Saharan Africa, where cardiovascular disease reaches epidemic proportions.

Methods: The Newer versus Older Antihypertensive Agents in African Hypertensive Patients (NOAAH) trial had recruited native African patients to compare the efficacy of various Antihypertensive drugs given once daily as single-pill combinations. Two centers engaged in Pulse wave analysis and measured carotid femoral pulse wave velocity (PWV). Statistical Methods included single and multiple linear regressions.

Results: Of 172 patients screened, 116 entered the ancillary study on central hemodynamics (51.3% women; mean age 52.7 years; untreated blood pressure 147.6/87.1 mm Hg).the augmentation indexes were higher (p<0.0001) in women than men, both peripherally (pAI, 11.1 vs.10.6%) and centrally (cAI, 39.0 vs. 28.0%). PWV (8.91 m/s) and central pulse pressure (cPP, 48.7 mm Hg) were similar (p>0.844) in both sexes. pAI and cAI increased with female sex and mean arterial pressure, but decreased with heart rate and body mass index. cPP increased with age and mean arterial pressure. PWV increased with age and mean arterial pressure. Patients with measurements above the age-specific thresholds determined in healthy Black South Africans amounted to 0 for cAI, 1 (1.2%) for cPP, and 11 (18.3%) for PWV.

Conclusion: NOAAH patients have measures of arterial stiffness similar to those of a healthy Black reference population with determinants as reported in the literature. Our observations Highlight the potential for the prevention of irreversible arterial damage by timely treating Sub-Saharan hypertensive patients to target blood pressure levels.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
132 - 132
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.108How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - M.K. Kamdem
AU  - E.A. Birinus
AU  - D. Lemougoum
AU  - B.C. Anisiuba
AU  - J. Kaptue
AU  - J. Staessen
AU  - M’buyamba Rene
AU  - A. Odili
PY  - 2013
DA  - 2013/11/11
TI  - P3.21 CENTRAL HEMODYNAMICS PARAMETERS IN BLACK HYPERTENSIVE PATIENTS BORN AND LIVING IN SUB-SAHARAN AFRICA
JO  - Artery Research
SP  - 132
EP  - 132
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.108
DO  - 10.1016/j.artres.2013.10.108
ID  - Kamdem2013
ER  -