P1.12 PREDICTIVE COMBINED ROLE OF CALCIUM SCORE AND CAROTIDIMT IN CORONARY ARTERY DISEASE

P. Meani; F. Cesana; A. Fallanca; C. Valsecchi; F. Musca; P. Campadello; F. Soriano; P. Faggiano; F. Rigo; A. Moreo; M.L. Muiesan; A. Paini; G.F. Mureddu; N. Gaibazzi; C. Giannattasio

doi:10.1016/j.artres.2013.10.043

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Volume 7, Issue 3-4, September 2013, Pages 114 - 114

P1.12 PREDICTIVE COMBINED ROLE OF CALCIUM SCORE AND CAROTIDIMT IN CORONARY ARTERY DISEASE

Authors

P. Meani¹^{, 2}, F. Cesana¹^{, 2}, A. Fallanca¹^{, 2}, C. Valsecchi², F. Musca¹, P. Campadello¹^{, 2}, F. Soriano¹^{, 2}, P. Faggiano³, F. Rigo⁴, A. Moreo¹, M.L. Muiesan⁵, A. Paini⁵, G.F. Mureddu⁶, N. Gaibazzi⁷, C. Giannattasio¹^{, 2}

¹Dipartimento Cardiotoracovascolare Cà GrandaNiguarda,Cardiologia IV, Milano, Italy

²Università degli Studi Milano Bicocca, Milano, Italy

³Cardiologia, Spedali Civili e Università di Brescia, Brescia, Italy

⁴Dipartimento di Cardiologia, Ospedale dell’angelo, Mestre - Venezia, Italy

⁵Clinica Medica Università di Brescia, Brescia, Italy

⁶Prevenzione Cardiovascolare Secondaria ed Ecocardiografia. Dip. di Malattie dell’Apparato Cardiocircolario, Roma, Italy

⁷Università degli Studi di Parma, Parma, Italy

Available Online 11 November 2013.

DOI: 10.1016/j.artres.2013.10.043 How to use a DOI?
Abstract: Objectives: up to date the assessment of coronary artery disease (CAD) risk is based mainly on the presence of CV risk factors. However, many markers of subclinical atherosclerosis has been demonstrated as powerful predictors of CV events. Aim of our study was to evaluate if non invasive US parameters, such as carotid properties and heart calcifications, are able to add information to the prediction of CAD.

Methods: In 405 in-patients with a clinical indication (overt angina and/or positive exercise test) for coronary angiography (CA), we measured blood pressures (BP), carotid intima-media thickness (IMT), local PWV and distensibility and quantified cardiac calcification by means of Calcium Score (CaS). After CA we divided the group in G1 (N=240) (patients with at least one coronary stenosis >50%), and G0 (N=165) (unaffected coronaries).

Results: G0 and G1 patients differed in age (67±10 vs 64±11yrs,p=0,01), but not in BMI (26±3.5 vs 28±16 kg/m2,p=0,03); G1 had higher BP (130±21/74±10 vs 136±18/77±11mmHg, p<0.02), carotid-IMT (705,4±155 vs 775,2±164mcm, p<0.0001), local PWV (8,9±2.8 vs 9,5±2,7m/s, p<0.01) and CaS(1,51±1,45 vs 2,56±1,86,p?). Among the considered US parameters, IMT and CaS were the best predictors of CAD, after adjusting for Framingham Risk Score (CaS: OD= 1, p<,001; IMT: OD=1,p=0,06).

Conclusions: Integrated US of heart and carotid artery can be very useful to detect subclinical ATS in medium-high risk patients, predicting significant CAD and adding qualitative information for better stratify the CV risk and improve clinical management.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 114 - 114
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.043 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - P. Meani
AU  - F. Cesana
AU  - A. Fallanca
AU  - C. Valsecchi
AU  - F. Musca
AU  - P. Campadello
AU  - F. Soriano
AU  - P. Faggiano
AU  - F. Rigo
AU  - A. Moreo
AU  - M.L. Muiesan
AU  - A. Paini
AU  - G.F. Mureddu
AU  - N. Gaibazzi
AU  - C. Giannattasio
PY  - 2013
DA  - 2013/11/11
TI  - P1.12 PREDICTIVE COMBINED ROLE OF CALCIUM SCORE AND CAROTIDIMT IN CORONARY ARTERY DISEASE
JO  - Artery Research
SP  - 114
EP  - 114
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.043
DO  - 10.1016/j.artres.2013.10.043
ID  - Meani2013
ER  -

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