Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 117 - 117

P1.26 MICROVASCULAR REACTIVITY PARAMETERS FAIL TO PREDICT CARDIOVASCULAR EVENTS IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Authors
J. Nemcsik1, O. Cseprekal5, J. Egresits5, Z. Járai2, K. Farkas3, E. Fodor6, L. Kerkovits4, L. Babos1, Németh Zs7, A. Marton7, G. Godina2, L. Sallai2, I. Kiss4, 6, A. Tislér5
1Department of Family Medicine, Semmelweis University, Budapest, Hungary
2St. Imre Teaching Hospital, Division of Cardiology, Budapest, Hungary
3St. Imre Teaching Hospital, Division of Angiology, Budapest, Hungary
4St. Imre Teaching Hospital, Division of Nephrology, Budapest, Hungary
5Ist Department of Internal Medicine, Semmelweis University, Budapest, Hungary
6B Braun Avitum Nephrological Network, Budapest, Hungary
7Uzsoki Hospital, Division of Nephrology, Budapest, Hungary
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.056How to use a DOI?
Abstract

Endothelial dysfunction, as assessed by laser-Doppler flowmetry (LDF) is an accepted method to measure microvascular reactivity, which correlates with cardiovascular risk factors in several patient populations. The aim of our prospective cohort study was to assess determinants of LDF parameters and to evaluate their prognostic values in patients with chronic kidney disease (CKD).

Ninety four hypertensive, stage 1–5 non-dialysis CKD patients had LDF measurements (iontophoresis of acethylcoline and sodium nitropusside in different doses and postocclusive reactive hyperaemia (PORH)). Baseline associations of these parameters with clinical, hemodynamic and laboratory characteristics were determined by linear regression models. Patients were followed for a median of 43 (37–55) months and the prognostic value of LDF parameters for cardiovascular (CV) events were evaluated by log-rank tests and Cox proportional hazard models.

The different LDF parameters did show strong correlation with each other. All iontophoresis parameters were strongly and negatively related to the presence of diabetes or antidiabetic treatment. All PORH parameters were strongly and negatively associated to central pulse pressure and the use of calcium channel blockers. During follow-up 26 CV events occurred. In multivariate analysis, only the presence of diabetes was found to be an independent predictor of CV events (RR: 3.85 (1.66–8.89), p=0.0012). None of the LDF parameters predicted CV outcome.

According to our results only the presence of diabetes, but not parameters of microvascular reactivity measured by iontophoresis or PORH have prognostic value for CV events in patients with CKD on conservative therapy. (Supported by Hungarian Kidney Foundation and Hungarian Society of Hypertension).

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
117 - 117
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.056How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - J. Nemcsik
AU  - O. Cseprekal
AU  - J. Egresits
AU  - Z. Járai
AU  - K. Farkas
AU  - E. Fodor
AU  - L. Kerkovits
AU  - L. Babos
AU  - Németh Zs
AU  - A. Marton
AU  - G. Godina
AU  - L. Sallai
AU  - I. Kiss
AU  - A. Tislér
PY  - 2013
DA  - 2013/11/11
TI  - P1.26 MICROVASCULAR REACTIVITY PARAMETERS FAIL TO PREDICT CARDIOVASCULAR EVENTS IN PATIENTS WITH CHRONIC KIDNEY DISEASE
JO  - Artery Research
SP  - 117
EP  - 117
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.056
DO  - 10.1016/j.artres.2013.10.056
ID  - Nemcsik2013
ER  -