P134 A New Method for Non-invasive Measurement of Arterial Wave Intensity, Speed and Reflection

DOI

10.2991/artres.k.191224.157How to use a DOI?

Abstract

Introduction: The ventricles accelerate and decelerate blood; the resulting disturbances propagate through the arterial system as waves. These waves contain clinically useful information: e.g. their magnitude and timing varies with cardiac performance and their speed depends on arterial stiffness. These properties can be studied using Wave Intensity Analysis (WIA) [1] and have been shown to be altered in heart failure [2]. Conventional WIA relies on invasive catheter measurements of blood pressure and velocity. We have developed and validated a new non-invasive ultrasound-based method that allows accurate WIA.

Methods: Employing a novel WIA formulation [3] based on diameter and velocity, and a ultrafast ultrasound imaging system (Verasonics, Kirkland, USA), wave intensity was measured in the abdominal aorta of rabbits. B-mode images were acquired at 1000 Hz, and diameter and velocity measured using standard cross-correlation techniques (the latter after spatio-temporal filtering to enhance the blood signal). Comparative measurements were made with a conventional WIA catheter-based system (Phillips Volcano, San Diego, USA). Ventricular dysfunction was induced by administering esmolol.

Results: Measured non-invasive peak wave intensities showed good agreement with catheter-based ones (ρ = 0.73, p = 0.04, n = 8). Changes in the intensity and timing of the forward compression wave could be detected 1 minute after esmolol administration (n = 10): peak intensity reduced by 30.3% (p = 0.003) and was delayed 9.30 ms (p = <0.001).

Conclusion: This new method enables wave intensities, reflections and speeds to be obtained non-invasively at any ultrasound accessible site. It could provide a clinically useful way to detect heart failure, and alteration of arterial tone and stiffness.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Ethan Rowland
AU  - Kai Riemer
AU  - Kevin Lichtenstein
AU  - Mengxing Tang
AU  - Peter Weinberg
PY  - 2020
DA  - 2020/02/17
TI  - P134 A New Method for Non-invasive Measurement of Arterial Wave Intensity, Speed and Reflection
JO  - Artery Research
SP  - S172
EP  - S172
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.157
DO  - 10.2991/artres.k.191224.157
ID  - Rowland2020
ER  -