Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S96 - S96

P55 Remote Ischaemic Preconditioning Reduces Cardiac Biomarkers During Vascular Surgery

Authors
Teele Kepler1, *, Karl Kuusik1, Urmas Lepner1, 2, Joel Starkopf1, 2, Mihkel Zilmer1, Jaan Eha1, 2, Kaido Paapstel2, Jaak Kals1, 2
1University of Tartu, Tartu, Estonia
2Tartu University Hospital, Tartu, Estonia
*Corresponding author. Email: teele.kepler@gmail.com
Corresponding Author
Teele Kepler
Available Online 17 February 2020.
DOI
10.2991/artres.k.191224.086How to use a DOI?
Abstract

Objectives: The primary aim of this study was to evaluate the effects of remote ischaemic preconditioning (RIPC) on preventing the leakage of cardiac damage biomarkers in patients undergoing vascular surgery.

Methods: Randomised, sham-controlled, double-blinded, single-centre study has been carried out. In recruitment patients undergoing open abdominal aortic aneurysm repair, surgical lower limb revascularisation surgery or carotid endarterectomy were enrolled non-consecutively. The RIPC protocol consisting of 4 cycles of 5 minutes of ischaemia, followed by 5 minutes of reperfusion, was applied. A RIPC or a sham procedure was performed noninvasively at the same time as the patient was prepared for anaesthesia. High sensitivity troponin T level was measured preoperatively as well as 2, 8 and 24 hours after surgery and pro b-type natriuretic peptide was measured preoperatively and 24 hours after surgery.

Results: There was significantly higher leakage of high sensitivity troponin T (peak change median 2 ng/L, IQR 0.9–6.2 ng/L vs 0.6 ng/L, IQR 0.7–2.1 ng/L, p = 0.0002) and pro b-type natriuretic peptide (change median 144 pg/mL, IQR 17–318 pg/mL vs 51 pg/mL, IQR 12–196 pg/mL, p = 0.02) in the sham group compared to the RIPC group.

Conclusion: RIPC reduces the leakage of high sensitivity troponin T and pro b-type natriuretic peptide. Therefore, it may reduce cardiac damage in patients undergoing non-cardiac vascular surgery. The clinical significance of RIPC has to be evaluated in larger studies excluding the factors known to influence its effect.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S96 - S96
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.086How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Teele Kepler
AU  - Karl Kuusik
AU  - Urmas Lepner
AU  - Joel Starkopf
AU  - Mihkel Zilmer
AU  - Jaan Eha
AU  - Kaido Paapstel
AU  - Jaak Kals
PY  - 2020
DA  - 2020/02/17
TI  - P55 Remote Ischaemic Preconditioning Reduces Cardiac Biomarkers During Vascular Surgery
JO  - Artery Research
SP  - S96
EP  - S96
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.086
DO  - 10.2991/artres.k.191224.086
ID  - Kepler2020
ER  -