P65 A Beat-to-Beat Quality Indicator Based on Piecewise Spatiotemporal Estimates of Carotid Pulse Wave Velocity Improves Correlation with Pulse Pressure

DOI

10.2991/artres.k.191224.096How to use a DOI?

Abstract

Background: Local carotid pulse wave velocity (PWV) estimation is challenging due to a complex anatomy and associated wave reflections [1]. Wave interference is both blood pressure (BP) and position dependent, hence causing nonlinearity in the spatiotemporal PWV estimation [2]. In lack of beat-to-beat quality assessment [3], we propose a method to quantify this nonlinearity and thereby introduce a quality indicator (QI) for reliable PWV estimation.

Methodology: Carotid artery ultrasound (Vantage64, VerasonicsInc., USA) was acquired from 10 subjects (38 ± 10 years) in six repeated measurements. Simultaneously, ECG (ECG100C, BIOPACInc., USA) and noninvasive BP (NOVA, FinapresMedicalSystems B.V., NL) were recorded. Signals were processed into distension waveforms to extract systolic foot (SF) and dicrotic notch (DN) fiducials [4]. Beat-to-beat PWV estimates at SF (PWVSF) and DN (PWVDN) were obtained via spatiotemporal fitting of respective fiducial timings against transducer element distances. The proposed nonlinearity QI was quantified as standard deviation of the error between full-length PWV estimate and piecewise PWV estimates from the proximal, middle and distal subset of transducer elements. Linear regression was performed between independent pulse pressure (PP, in 2 [mmHg] intervals) and dependent PWV (means of all estimates) to validate QI according to Bramwell-Hill [5].

Results: When qualifying PWV estimates with QI ≤1 [m/s] we observed a significant R² increase for both PWVSF (0.22 to 0.41, with decreased RMSE from 0.47 to 0.42 [m/s]) and PWVDN (0.21 to 0.53, although with constant RMSE of 0.32 [m/s]) as shown in annexed figure.

Conclusion: The proposed beat-to-beat QI accounts for significant variability in the PWV-PP relation, albeit at substantial data reduction. Therefore, the QI may facilitate real-time quality assessment towards reliable local PWV estimation. The unexplained variability remainder requires further investigations for confounding variables.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Fabian Beutel
AU  - Chris Van Hoof
AU  - Evelien Hermeling
PY  - 2020
DA  - 2020/02/17
TI  - P65 A Beat-to-Beat Quality Indicator Based on Piecewise Spatiotemporal Estimates of Carotid Pulse Wave Velocity Improves Correlation with Pulse Pressure
JO  - Artery Research
SP  - S108
EP  - S109
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.096
DO  - 10.2991/artres.k.191224.096
ID  - Beutel2020
ER  -