P10 Oscillatory Flow Patterns in Peripheral Conduit Artery are Related to Central Arterial Stiffness in Healthy Subjects

DOI

10.2991/artres.k.191224.045How to use a DOI?

Abstract

Background: Studies in endothelial cell cultures show that oscillating flow pattern leads to endothelial dysfunction [1]. The only factor known to contribute towards oscillatory flows is peripheral arterial conductance [2]. However, contribution of alterations in central arterial properties to oscillatory flows is not established.

Methods: Healthy subjects (n = 28) (Age 51.0 ± 9.4 years) with resting retrograde flow in brachial artery were recruited for the study. Pulsed-wave doppler (M7, MindRay) was used for estimation of blood flow velocity with simultaneous diameter acquisition for shear rate calculation. Oscillatory Shear Index (OSI) was calculated by: Retrograde shear rate/(Anterograde shear rate + Retrograde shear rate). Local and regional central arterial stiffness was estimated using carotid distensibility, compliance and Incremental Elastic Modulus (IEM) (Medical Imaging Applications) and carotid-femoral Pulse Wave Velocity (PWV) using applanation tonometry (SphygmocorÒ) respectively. Peripheral vascular stiffness was assessed by carotid-radial PWV. Forearm vascular resistance was estimated using peripheral mean arterial pressure and mean anterograde flow. Carotid-Intima-Media-Thickness (CIMT) was measured using B-mode ultrasound for subclinical atherosclerotic burden estimation.

Results: Retrograde flow showed a significant positive correlation with IEM, CIMT and Augmentation Index (AI) (r = 0.64, 0.47 and 0.62 respectively) (Figures 1 and 2). A significant negative correlation was seen between retrograde flow and carotid compliance (r = –0.58). OSI correlated positively with IEM (r = 0.56) and AI (r = 0.45).

Conclusion: Results of the current study suggest that oscillatory flow patterns in peripheral conduit artery could originate due to decrease in central arterial compliance possibly because of its impact on the incident pressure wave.

Figure 1

Correlation between brachial artery mean retrograde flow at rest and carotid artery Incremental Elastic Modulus.

Figure 2

Correlation between brachial artery mean retrograde flow at rest and aortic Augmentation Index.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Smriti Badhwar
AU  - Dinu Chandran
AU  - Ashok Jaryal
AU  - Rajiv Narang
AU  - Chetan Patel
AU  - Kishore Kumar Deepak
PY  - 2020
DA  - 2020/02/15
TI  - P10 Oscillatory Flow Patterns in Peripheral Conduit Artery are Related to Central Arterial Stiffness in Healthy Subjects
JO  - Artery Research
SP  - S52
EP  - S53
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.045
DO  - 10.2991/artres.k.191224.045
ID  - Badhwar2020
ER  -