P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection

DOI

10.2991/artres.k.191224.036How to use a DOI?

Abstract

Background: Aortic dissection is a devastating condition, beginning with a tear through from intima to the medial layer, leading to splitting of aortic layers and creating the false and true lumen with a septum (or flap). Little is known about the properties of the dissection flap.

Aim: To determine the time-dependent (creep) biomechanical behaviour and biochemical properties of the dissection flap.

Methods: 15 descending thoracic aorta samples were obtained from patients undergoing elective surgery for chronic dissected aneurysms. Creep was measured using a non-destructive ball indentation technique utilising a stainless-steel ball over 5 hours. Images were obtained using a long focal distance objective microscope. Remaining tissues were used to determine elastin and glycosaminoglycan (GAG) levels.

Results: The elastic modulus (tissue stiffness) was 64.68 ± 11 kPa and 55.1 ± 9.5 kPa for the flap and true aortic wall respectively. Over 5 hours, the central deformation of the flap tissue was found to be 0.52 ± 0.07 mm as compared to 0.67 ± 0.07 mm for the true aortic wall (p < 0.05). Elastin levels were 126.8 ± 37.25 mg/mg for the flap and 79.82 ± 19.64 mg/mg for the true aortic wall (p < 0.05). The GAG levels were 4.2 mg/mg ± 0.9 mg/mg for the flap and 3.0 ± 0.5 mg/mg (p < 0.05).

Conclusion: The dissection flap exhibits reduced time-dependent deformation and has higher levels of elastin and GAG relative to the aortic wall. These findings may help develop bespoke surgical treatments based on the unique biomechanical and biochemical properties that have been identified.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)
View full text (HTML)

TY  - JOUR
AU  - Phakakorn Panpho
AU  - Hannah Davies
AU  - Mark Field
AU  - Jillian Madine
AU  - Ying Yang
AU  - Riaz Akhtar
PY  - 2020
DA  - 2020/02/15
TI  - P1 Biomechanical Properties of the Aortic Dissection Flap in Chronic Aortic Dissection
JO  - Artery Research
SP  - S43
EP  - S43
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.036
DO  - 10.2991/artres.k.191224.036
ID  - Panpho2020
ER  -