3.7 Exercise Systolic Blood Pressure Response And Incident Depressive Symptoms – The Maastricht Study

Tan Lai Zhou; Abraham Kroon; Ronald Henry; Annemarie Koster; Pieter Dagnelie; Hans Bosma; Marleen van Greevenbroek; Carla van der Kallen; Casper Schalkwijk; Anke Wesselius; Koen Reesink; Sebastian Köhler; Miranda Schram; Coen Stehouwer; Thomas van Sloten

doi:10.2991/artres.k.191224.020

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Volume 25, Issue Supplement 1, December 2019, Pages S28 - S28

3.7 Exercise Systolic Blood Pressure Response And Incident Depressive Symptoms – The Maastricht Study

Authors

Tan Lai Zhou¹^{, 2}^{, *}, Abraham Kroon¹^{, 2}, Ronald Henry¹^{, 2}, Annemarie Koster³^{, 4}, Pieter Dagnelie¹^{, 2}, Hans Bosma³^{, 4}, Marleen van Greevenbroek⁴^{, 2}, Carla van der Kallen⁴^{, 2}, Casper Schalkwijk⁴^{, 2}, Anke Wesselius⁴, Koen Reesink²^{, 4}, Sebastian Köhler⁵^{, 6}, Miranda Schram¹^{, 2}, Coen Stehouwer¹^{, 2}, Thomas van Sloten¹^{, 2}^{, 7}^{, 8}

¹Maastricht University Medical Centre, Maastricht, The Netherlands

²CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands

³CAPHRI Care and Public Health Research Institute, Maastricht, The Netherlands

⁴Maastricht University, Maastricht, The Netherlands

⁵Alzheimer Centre Limburg, Maastricht University Medical Centre, Maastricht, The Netherlands

⁶MHeNs School for Mental Health and Neuroscience, Maastricht, The Netherlands

⁷Université Paris Descartes, Paris, France

⁸INSERM Paris Cardiovascular Research Centre, Paris, France

^*Corresponding author. Email: tanlai.zhou@mumc.nl

Corresponding Author

Tan Lai Zhou

Available Online 15 February 2020.

DOI: 10.2991/artres.k.191224.020 How to use a DOI?
Abstract: Background: Exaggerated exercise systolic blood pressure (SBP) is a modifiable risk factor associated with vascular dysfunction. Vascular dysfunction may contribute to the development of late-life depression, but the association between exercise SBP and incident depressive symptoms is unknown. Therefore, we investigated whether an exaggerated exercise SBP is associated with a higher risk of depressive symptoms over time.

Methods: Longitudinal data from the population-based Maastricht Study, with only individuals free of depressive symptoms at baseline included (n = 2,121; 51.3% men; age 59.5 ± 8.5 years). Exercise SBP was measured at baseline with a submaximal exercise cycle test. We calculated a composite score of exercise SBP based on 4 standardized exercise SBP measures: SBP at moderate workload, SBP at peak exercise, SBP change per minute during exercise and SBP 4 minutes after exercise. Clinically relevant depressive symptoms were determined annually at follow-up and defined as a Patient Health Questionnaire score of > = 10.

Results: After a mean follow-up of 3.9 years, 175 participants (8.3%) had incident clinically relevant depressive symptoms. A1 standard deviation higher exercise SBP composite score was associated with a higher incidence of clinically relevant depressive symptoms (hazard ratio: 1.27 [95% confidence interval: 1.04–1.54]). Results were adjusted for age, sex, education level, glucose metabolism status, lifestyle, cardiovascular risk factors, resting SBP and cardiorespiratory fitness.

Conclusion: A higher exercise SBP response is associated with a higher incidence of clinically relevant depressive symptoms.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S28 - S28
Publication Date: 2020/02/15
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.020 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Tan Lai Zhou
AU  - Abraham Kroon
AU  - Ronald Henry
AU  - Annemarie Koster
AU  - Pieter Dagnelie
AU  - Hans Bosma
AU  - Marleen van Greevenbroek
AU  - Carla van der Kallen
AU  - Casper Schalkwijk
AU  - Anke Wesselius
AU  - Koen Reesink
AU  - Sebastian Köhler
AU  - Miranda Schram
AU  - Coen Stehouwer
AU  - Thomas van Sloten
PY  - 2020
DA  - 2020/02/15
TI  - 3.7 Exercise Systolic Blood Pressure Response And Incident Depressive Symptoms – The Maastricht Study
JO  - Artery Research
SP  - S28
EP  - S28
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.020
DO  - 10.2991/artres.k.191224.020
ID  - Zhou2020
ER  -

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