4.6 Effects of Combined Therapy of Empagliflozin and Linagliptin Versus Metformin and Insulin Glargine on Blood Pressure and Vascular Function in Patients with Type 2 Diabetes

DOI

10.2991/artres.k.191224.027How to use a DOI?

Abstract

Background: Combination of insulin with oral antidiabetic drugs is a valid option, but oral combination therapy emerged as an alternative treatment in type 2 diabetes (T2DM). However, the effects on blood pressure (BP) and vascular function of such combination therapies is less clear.

Methods: In this study 101 patients with T2DM were randomized to receive either empagliflozin 10 mg and linagliptin 5 mg (E+L group) orally or metformin and insulin glargine (M+I group, with dose adjustments according to glucose levels), for 3 months. Patients underwent BP and vascular examination at baseline and after 12 weeks of treatment, including measurement of office and ambulatory BP and vascular function under clinical and ambulatory conditions by validated systems.

Results: In comparison to baseline, office, 24-hour ambulatory BP and central blood and pulse pressure (PP) values decreased significantly after 12 weeks of treatment with E+L, whereas there was no significant change in vascular parameters in the M+I group (Table 1). Comparing the 2 groups, there were significant decreases in 24-h ambulatory peripheral systolic (mean difference between the 2 groups: −5.2 ± 1.5 mmHg, p = 0.004), diastolic BP (−1.9 ± 1.0 mmHg, p = 0.036) and PP (−3.3 ± 1.0 mmHg, p = 0.007) in favour of E+L. Central systolic BP (−5.56 ± 1.9 mmHg, p = 0.009), forward pressure pulse height (−2.0 ± 0.9 mmHg, p = 0.028) and 24-h ambulatory central systolic (−3.6 ± 1.4 mmHg, p = 0.045), diastolic BP (−1.95 ± 1.1 mmHg, p = 0.041) and 24-h pulse wave velocity (−0.14 ± 0.05 m/s, p = 0.043) were reduced to a greater extent in the E+L group than in the M+I group.

	E + L			M + I
	Baseline	12 weeks	p-value	Baseline	12 weeks	p-value
Peripheral (brachial) BP values
24-h ambulatory SBP [mmHg]	131 ± 10.9	127 ± 8.8	<0.001	131 ± 9.7	131 ± 8.6	0.438
24-h ambulatory DBP [mmHg]	81.5 ± 7.1	79.7 ± 7.0	0.013	81 ± 7.1	81 ± 7.5	0.976
Clinical (laboratory) central vascular parameters
Central SBP [mmHg]	123 ± 9.6	117 ± 10.4	<0.001	121 ± 9.9	121 ± 8.3	0.944
Central PP [mmHg]	44.4 ± 8.0	41.4 ± 6.6	0.004	43.5 ± 8.6	42.8 ± 7.5	0.471
Fonvard pressure pulse height [mmHg]	33 ± 5.7	30.2 ± 4.6	<0.001	32.5 ± 5.6	31.8 ± 4.5	0.216
Central office P\W [ms]	82 ± 1.6	8.0 ± 1.5	0.039	8.4 ± 1.3	8.3 ± 12	0.400
24-h ambulatory central vascular parameters
Central 24-h SBP [mmHg]	120.5 ± 9.3	117.3 ± 7.9	0.007	121 ± 9.1	121 ± 8.0	0.608
Central 24-h DBP [mmHg]	83.2 ± 7.3	81.1 ± 6.9	0.016	82.4 ± 7.1	82.4 ± 7.7	0.928
Central 24-h PWV [ms]	8.9 ± 1.3	8.8 ± 1.3	0.010	9.0 ± 1.4	90 ± 1.3	0.349

Changes in BP and vascular function after 12 weeks of treatment with E-L and M-I in comparison to baseline. Data are given as mean ± standard deviation. E, empagliflozin; L, linagliptm; M, metformin I, insulin glargine; SBP – systolic hood pressure; DBP, diastolic hood pressure; PP, pulse pressure; PWV, pulse wave velocity.

Conclusion: The combination of E+L significantly improves BP and vascular function in contrast to the combination of M+I.

Copyright

© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Christian Ott
AU  - Susanne Jung
AU  - Agnes Bosch
AU  - Dennis Kannenkeril
AU  - Kristina Striepe
AU  - Roland Schmieder
PY  - 2020
DA  - 2020/02/15
TI  - 4.6 Effects of Combined Therapy of Empagliflozin and Linagliptin Versus Metformin and Insulin Glargine on Blood Pressure and Vascular Function in Patients with Type 2 Diabetes
JO  - Artery Research
SP  - S35
EP  - S35
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.027
DO  - 10.2991/artres.k.191224.027
ID  - Ott2020
ER  -