Artery Research

Volume 26, Issue 3, September 2020, Pages 148 - 153

The Association between Retinal and Central Pulse Wave Velocity in the Elderly

Authors
Mahdieh Rezaeian1, S. Mojtaba Golzan2, Alberto P. Avolio3, Stuart Graham1, Mark Butlin3, *
1Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
2Vision Science Group, Graduate School of Health, University of Technology Sydney, Sydney, Australia
3Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia
*Corresponding author. Email: mark.butlin@mq.edu.au
Corresponding Author
Mark Butlin
Received 20 December 2019, Accepted 31 January 2020, Available Online 11 February 2020.
DOI
10.2991/artres.k.200203.001How to use a DOI?
Keywords
Retinal artery; small vessel; arterial stiffness; pulse wave velocity
Abstract

Purpose: The retina provides a non-invasive window to monitor microvascular circulation. Carotid-femoral Pulse Wave Velocity (cfPWV) is an indicator of large artery stiffness and is associated with systemic cardiovascular diseases. This study investigates whether Retinal artery PWV (rPWV) reflects cfPWV changes in an elderly cohort.

Methods: A total of 37 elderly participants (28 female, age 79 ± 5 years) were studied. Participants with a history of diabetes, glaucoma, and any neurological or eye-related disorders were excluded. Twenty four subjects were taking antihypertensive medication. A 60-s recording of retinal arterial diameter changes were captured (25 Hz frame rate, Dynamic Vessel Analyzer). Systolic blood pressure, Diastolic Blood Pressure (DBP), cfPWV and Intraocular Pressure (IOP) were measured. A custom-written algorithm was used to extract pulse amplitudes from retinal arterial diameters within one- and three-disc diameters from the optic disc. rPWV was designated as the ratio of the distance between two sites along the artery to the time delay between pulses. Predictors of rPWV were assessed by linear regression and parameter selection techniques.

Results: There was a positive correlation between rPWV and cfPWV (Pearson’s correlation coefficient 0.82, p < 0.001). In parameter selection models, cfPWV, transmural pressure (DBP–IOP), male sex, and IOP were isolated as predictors of rPWV.

Conclusion: This study found a positive correlation between rPWV and cfPWV in an elderly cohort. This indicates that microvessel remodelling that parallels large vessel remodelling is able to be detected using rPWV measurement. Further longitudinal studies are required to elucidate the predictive value of screening rPWV in systemic cardiovascular abnormalities.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
26 - 3
Pages
148 - 153
Publication Date
2020/02/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.200203.001How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Mahdieh Rezaeian
AU  - S. Mojtaba Golzan
AU  - Alberto P. Avolio
AU  - Stuart Graham
AU  - Mark Butlin
PY  - 2020
DA  - 2020/02/11
TI  - The Association between Retinal and Central Pulse Wave Velocity in the Elderly
JO  - Artery Research
SP  - 148
EP  - 153
VL  - 26
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.200203.001
DO  - 10.2991/artres.k.200203.001
ID  - Rezaeian2020
ER  -