Artery Research

Volume 12, Issue C, December 2015, Pages 33 - 33

P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME?

Authors
Lorenzo Ghiadoni*1, Rosa Maria Bruno2, Francesco Regoli1, Giuseppe Penno1, Stefano Taddei1
1University of Pisa, Pisa, Italy
2Institute of Clinical Physiology, CNR, Pisa, Italy
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.318How to use a DOI?
Abstract

Objective: Methodological issues are major reasons preventing the use of endothelial function testing in clinical practice This study aimed to address the relationship between two non-invasive techniques, brachial artery flow-mediated dilation (FMD) and as reactive hyperemia index (RHI), comparing also lower (forearm, L) and upper (arm, U) cuff occlusion.

Methods: In 17 young healthy subjects (9 males, age 29±4 years) FMD (Cardiovascular Suite, Quipu s.r.l., Pisa, Italy). and RHI (EndoPAT 2000, Itamar Medical, Israel) were measured simultaneously in two separate occasions using 5 minutes of L- or U-ischemia. Baseline and Hyperemic Shear rate (SR) were also computed.

Results: L-FMD (7.32±4.87%) and L-RHI (0,61±0.29%) were significantly lower (p<0.05 and p<0.01, respectively) as compared to U-FMD (10.48±5.67%) and U-RHI (0.86±0.23%). L-RHI and U-RHI tended to be related (r=0.49; p=0.06), while L-FMD and U-FMD were not (r=0.39; p=0.12),

L-FMD was significantly related to L-SR (r=0.62; p<0.01), but not to L-RHI (r=0.17; p=0.54). L-RHI was not significantly correlated with L-SR (r=0.24; p=0,38). U-RHI was related to U-FMD (r=0.50; p<0.05) and to U-SR (r=0.50, p<0.04). In multiple regression analysis (full model: r2=0.23) U-FMD but not U-SR was associated with U-RHI (r2=0.20; p=0.05).

Conclusions: In healthy subjects, the assessment of FMD and RHI with lower and upper cuff occlusion is not equivalent. L-FMD, but not U-FMD is related to SR increase, thus possibly representing a better marker for conduit artery endothelial function. U-RHI and U-FMD possibly provide similar information on vascular reactivity. Caution is deemed in interpreting studies conducted with different methodologies.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
33 - 33
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.318How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Lorenzo Ghiadoni*
AU  - Rosa Maria Bruno
AU  - Francesco Regoli
AU  - Giuseppe Penno
AU  - Stefano Taddei
PY  - 2015
DA  - 2015/11/23
TI  - P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME?
JO  - Artery Research
SP  - 33
EP  - 33
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.318
DO  - 10.1016/j.artres.2015.10.318
ID  - Ghiadoni*2015
ER  -