P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME?
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- Abstract
Objective: Methodological issues are major reasons preventing the use of endothelial function testing in clinical practice This study aimed to address the relationship between two non-invasive techniques, brachial artery flow-mediated dilation (FMD) and as reactive hyperemia index (RHI), comparing also lower (forearm, L) and upper (arm, U) cuff occlusion.
Methods: In 17 young healthy subjects (9 males, age 29±4 years) FMD (Cardiovascular Suite, Quipu s.r.l., Pisa, Italy). and RHI (EndoPAT 2000, Itamar Medical, Israel) were measured simultaneously in two separate occasions using 5 minutes of L- or U-ischemia. Baseline and Hyperemic Shear rate (SR) were also computed.
Results: L-FMD (7.32±4.87%) and L-RHI (0,61±0.29%) were significantly lower (p<0.05 and p<0.01, respectively) as compared to U-FMD (10.48±5.67%) and U-RHI (0.86±0.23%). L-RHI and U-RHI tended to be related (r=0.49; p=0.06), while L-FMD and U-FMD were not (r=0.39; p=0.12),
L-FMD was significantly related to L-SR (r=0.62; p<0.01), but not to L-RHI (r=0.17; p=0.54). L-RHI was not significantly correlated with L-SR (r=0.24; p=0,38). U-RHI was related to U-FMD (r=0.50; p<0.05) and to U-SR (r=0.50, p<0.04). In multiple regression analysis (full model: r2=0.23) U-FMD but not U-SR was associated with U-RHI (r2=0.20; p=0.05).
Conclusions: In healthy subjects, the assessment of FMD and RHI with lower and upper cuff occlusion is not equivalent. L-FMD, but not U-FMD is related to SR increase, thus possibly representing a better marker for conduit artery endothelial function. U-RHI and U-FMD possibly provide similar information on vascular reactivity. Caution is deemed in interpreting studies conducted with different methodologies.
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TY - JOUR AU - Lorenzo Ghiadoni* AU - Rosa Maria Bruno AU - Francesco Regoli AU - Giuseppe Penno AU - Stefano Taddei PY - 2015 DA - 2015/11/23 TI - P7.15 REACTIVE HYPEREMIA INDEX AND FLOW MEDIATED DILATION WITH UPPER- AND LOWER-ARM CUFF OCCLUSION: ARE THEY MEASURING THE SAME? JO - Artery Research SP - 33 EP - 33 VL - 12 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2015.10.318 DO - 10.1016/j.artres.2015.10.318 ID - Ghiadoni*2015 ER -