Artery Research

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Volume 12, Issue C, December 2015, Pages 28 - 29

P6.17 CARDIOVASCULAR RISK FACTORS CONTRIBUTE TO THE VARIANCE OF WALL-TO-LUMEN RATIO

Authors
Rytis Masiliunas*1, Kristina Ryliskiene1, 2, Ligita Ryliskyte3, 4, Rokas Navickas3, 4, Jurgita Kuzmickiene1, 2, Jolita Badariene3, 4, Dalius Jatuzis1, 2, Aleksandras Laucevicius3, 4
1Department of Neurology, Vilnius University Hospital Santariskiu klinikos, Vilnius, Lithuania
2Clinic of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
3Department of Cardiovascular Medicine, Vilnius University Hospital Santariskiu klinikos, Vilnius, Lithuania
4Clinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.301How to use a DOI?
Abstract

Background: Common carotid artery intima-media thickness (cIMT) is an accepted ultrasound marker of subclinical atherosclerosis. It is argued that increase in cIMT may also reflect nonatherosclerotic thickening, thus, lumen diameter could be taken into account. A common approach to account for lumen diameter is wall-to-lumen ratio (WLR), however, its precise relations to cardiovasular risk factors remain unclear. We attempted to compare the contribution of cardiovascular risk factors to the variance in cIMT and WLR.

Methods: Noninvasive measurements of cIMT and WLR were made with high-resolution ultrasonography in 5,983 subjects. They were male aged 40 to 55 and female aged 50 to 65 without previous cardiovascular events, participating in the Lithuanian High Cardiovascular Risk primary prevention program. We performed a multiple linear regression on cIMT and WLR incorporating traditional and less traditional cardiovascular risk factors.

Results: Mean left and right cIMT was 0.66 ± 0.12 mm and 0.65 ± 0.11 mm respectively, whereas mean WLR was 0.092 ± 0.015. We found that cardiovascular risk factors could explain 8.9% of left cIMT and 8.3% of right cIMT. Strikingly, traditional and less traditional factors (namely age, male sex, LDL/HDL ratio, mean arterial blood pressure and triglyceride) contributed to a significantly larger proportion of WLR variance, amounting to 14.2%.

Conclusions: Adjustment for carotid lumen diameter in analyses evaluating common carotid artery intima-media thickness should be considered. The precise role of WLR as an ultrasound marker of subclinical atherosclerosis remains a topic of interest for future research.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
12 - C
Pages
28 - 29
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.301How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Rytis Masiliunas*
AU  - Kristina Ryliskiene
AU  - Ligita Ryliskyte
AU  - Rokas Navickas
AU  - Jurgita Kuzmickiene
AU  - Jolita Badariene
AU  - Dalius Jatuzis
AU  - Aleksandras Laucevicius
PY  - 2015
DA  - 2015/11/23
TI  - P6.17 CARDIOVASCULAR RISK FACTORS CONTRIBUTE TO THE VARIANCE OF WALL-TO-LUMEN RATIO
JO  - Artery Research
SP  - 28
EP  - 29
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.301
DO  - 10.1016/j.artres.2015.10.301
ID  - Masiliunas*2015
ER  -