P3.21 ASSOCIATIONS OF INSULIN-LIKE GROWTH FACTOR AND ITS BINDING PROTEIN-2 AND 3 WITH BLOOD PRESSURE AND ARTERIAL STRUCTURE AND FUNCTION IN HYPERTENSIVE PERIMENOPAUSAL WOMEN

DOI

10.1016/j.artres.2015.10.244How to use a DOI?

Abstract

IGFs and their binding proteins are increasingly recognized as important in understanding the pathogenesis of cardiovascular disease. During the transition from premenopause to postmenopause, many women experience weight gain, hence we hypothesized that circulating growth hormones can play a role in the pathogenesis of hypertension and subclinical organ damage in perimenopausal women.

The study included 152 women with newly diagnosed, never treated hypertension and 40 normotensive age-matched controls (mean age 51.73±1.82 years). In all subjects 24-hr ABPM, carotid ultrasound with measurement of intima-media thickness (IMT), and carotid-femoral pulse wave velocity (PWV) measurement (Sphygmocor) were performed. Serum levels of IGF-I, IGFBP2 and IGFBP3 and were measured using an immunochemical assay.

Results: Postmenopausal women (n=93) did not differ from premenopausal (n=99) in respect to mean arterial pressure (normotensive 85.2±5.6 vs 84.4±4.9 mmHg; hypertensive 99.5±5.9 vs 98.8±5.3 mmHg). Hypertensive women had significantly lower IGFBP-2 level than normotensive (162±83 vs 273±101 ug/l, p<0.001), groups did not differ in IGF and IGFBP3 concentration. IGFPB2 was the independent predictor of blood pressure in the examined group. In multivariate regression analysis after adjustment to age and BMI – IGFBP2 remained significantly negatively correlated to BP (β=−0.33, p=0.001). Odds ratio for hypertension per SD decrease in IGFBP2 was 3.43 (95% CI 1.65–7.13). IGFBP2 was independently of BP related with PWV (β=−0.22, p=0.05) but not with IMT (β=−0.14, p=0.22).

Conclusions: In perimenopausal women decreased IGFBP2 level may play a role in the blood pressure regulation. Further longitudinal studies are needed to elucidate the cardioprotective role of IGFBP2.

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TY  - JOUR
AU  - Agnieszka Olszanecka*
AU  - Kalina Kawecka-Jaszcz
AU  - Danuta Czarnecka
PY  - 2015
DA  - 2015/11/23
TI  - P3.21 ASSOCIATIONS OF INSULIN-LIKE GROWTH FACTOR AND ITS BINDING PROTEIN-2 AND 3 WITH BLOOD PRESSURE AND ARTERIAL STRUCTURE AND FUNCTION IN HYPERTENSIVE PERIMENOPAUSAL WOMEN
JO  - Artery Research
SP  - 15
EP  - 15
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.244
DO  - 10.1016/j.artres.2015.10.244
ID  - Olszanecka*2015
ER  -