P3.4 PULSE WAVE REFLECTIONS AND THEIR DIURNAL CHANGES IN PATIENTS WITH MARFAN SYNDROME COMPARED TO HEALTHY CONTROLS

DOI

10.1016/j.artres.2015.10.229How to use a DOI?

Abstract

Introduction: Patients with Marfan syndrome may suffer from a variety of symptoms, including changes of the cardiovascular system. The aim of this study was to perform ambulatory 24 hour blood pressure and pulse wave measurements in a group of Marfan patients and a group of healthy controls and to analyse wave reflections.

Methods: All measurements were obtained with the Mobil-O-Graph device. Reflection magnitude (RM) was calculated with the inbuilt ARCSolver algorithms and averaged during daytime and nighttime. The study included 27 patients with Marfan syndrome and 27 healthy controls. Matching criteria were age (39 years mean in both groups), sex (14 female) and daytime brachial systolic blood pressure (119 mmHg mean in both groups). Patients with Marfan syndrome were significantly taller than controls (190 cm vs. 174 cm).

Results: Reflection magnitude increased significantly during night in both groups (Marfan: 57.8 day, 66.6 night; controls: 58.6 day, 68.7 night). Differences between groups were not significant both day and night. Correlations between RM and body height were positive in Marfan patients (R=0.36 day, R=0.33 night) but negative in controls (R=−0.47 day, R=−0.66 night), showing a significantly different trend (p<0.01).

Conclusions: There are similar levels and diurnal changes of reflection magnitude in patients with Marfan syndrome and healthy controls, but correlations of RM to body height are significantly different in Marfans and controls. This finding may relate to structural changes of the cardiovascular system associated with Marfan syndrome.

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TY  - JOUR
AU  - Bernhard Hametner*
AU  - Matthias Hillebrand
AU  - Ghazaleh Nouri
AU  - Stephanie Parragh
AU  - Jelena Köster
AU  - Kai Mortensen
AU  - Achim Schwarz
AU  - Yskert von Kodolitsch
AU  - Siegfried Wassertheurer
PY  - 2015
DA  - 2015/11/23
TI  - P3.4 PULSE WAVE REFLECTIONS AND THEIR DIURNAL CHANGES IN PATIENTS WITH MARFAN SYNDROME COMPARED TO HEALTHY CONTROLS
JO  - Artery Research
SP  - 11
EP  - 11
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.229
DO  - 10.1016/j.artres.2015.10.229
ID  - Hametner*2015
ER  -