Artery Research

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Volume 12, Issue C, December 2015, Pages 11 - 12

P3.5 TYPE 2 DIABETES EXACERBATES CAROTID ARTERY ECHOGENICITY AND CENTRAL ARTERY STIFFNESS IN MIDDLE-AGED AND OLDER INDIVIDUALS

Authors
Kunihiko Aizawa*1, 2, Francesco Casanova1, 2, Dave Mawson1, 2, Salim Elyas1, 2, Damilola Adingupu1, 2, Kim Gooding1, 2, David Strain1, 2, Angela Shore1, 2, Phillip Gates1, 2
1University of Exeter Medical School, Exeter, UK
2NIHR Exeter Clinical Research Facility, Exeter, UK
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.230How to use a DOI?
Abstract

Grey scale median of the common carotid artery intima-media complex (IM-GSM) characterizes the composition of the arterial wall and low IM-GSM reflects more generalized atherosclerotic vulnerability. However, it is unclear whether the presence of DM itself affects IM-GSM, similar to that observed with aortic stiffness. We measured IM-GSM and aortic stiffness in middle-aged and older individuals with and without DM. We included 264 individuals with DM (DM+; 67.0±8.9yrs, 83F) and 226 individuals without DM (DM-; 66.3±9.3yrs, 81F). Ultrasound images of the common carotid artery intima-media thickness (IMT) were obtained and IM-GSM was analysed using semi-automated edge-detection software. Aortic stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV) using a SphygmoCor® device. IM-GSM was significantly lower in DM+ than DM− (103.6±1.5au vs 113.4±1.6au, p<0.05) after adjustment for age and sex. Adjustments for cardiovascular disease (CVD), hypertension (HT), statin treatment and IMT did not change the finding. cfPWV was significantly higher in DM+ than DM- (10.2±1.0m/s vs 9.1±1.0m/s, p<0.05) after adjustment for age, sex and mean arterial pressure. Adjustments for CVD, HT, statin treatment and heart rate did not change the finding. With further adjustment for HbA1c, cfPWV became similar between the groups, but IM-GSM remained lower in DM+ than DM- (p<0.05). These results demonstrate that the presence of DM unfavourably alters both IM-GSM and cfPWV in middle-aged and older individuals, and that impaired glycaemic control (HbA1c) only accounts for the difference in cfPWV. These findings suggest the presence of an additional factor(s) together with glycaemic control that influence IM-GSM in DM.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
12 - C
Pages
11 - 12
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.230How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Kunihiko Aizawa*
AU  - Francesco Casanova
AU  - Dave Mawson
AU  - Salim Elyas
AU  - Damilola Adingupu
AU  - Kim Gooding
AU  - David Strain
AU  - Angela Shore
AU  - Phillip Gates
PY  - 2015
DA  - 2015/11/23
TI  - P3.5 TYPE 2 DIABETES EXACERBATES CAROTID ARTERY ECHOGENICITY AND CENTRAL ARTERY STIFFNESS IN MIDDLE-AGED AND OLDER INDIVIDUALS
JO  - Artery Research
SP  - 11
EP  - 12
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.230
DO  - 10.1016/j.artres.2015.10.230
ID  - Aizawa*2015
ER  -