P109 PROGRESSION OF AORTIC ARCH CALCIFICATION AFTER KIDNEY TRANSPLANT AND ITS IMPORTANCE IN PREDICTING CARDIOVASCULAR RISK: SINGLE-CENTER 2-YEAR FOLLOW-UP STUDY

Agne Laucyte-Cibulskiene; Evelina Boreikaite; Gediminas Aucina; Migle Gudynaite; Ilona Rudminiene; Sigita Anisko; Loreta Vareikiene; Liutauras Gumbys; Nerijus Teresius; Dileta Valanciene; Ligita Ryliskyte; Laurynas Rimsevicius; Marius Miglinas; Kestutis Strupas

doi:10.1016/j.artres.2017.10.140

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Volume 20, Issue C, December 2017, Pages 91 - 92

P109 PROGRESSION OF AORTIC ARCH CALCIFICATION AFTER KIDNEY TRANSPLANT AND ITS IMPORTANCE IN PREDICTING CARDIOVASCULAR RISK: SINGLE-CENTER 2-YEAR FOLLOW-UP STUDY

Authors

Agne Laucyte-Cibulskiene¹, Evelina Boreikaite², Gediminas Aucina², Migle Gudynaite¹, Ilona Rudminiene¹, Sigita Anisko¹, Loreta Vareikiene¹, Liutauras Gumbys³, Nerijus Teresius³, Dileta Valanciene³, Ligita Ryliskyte⁴, Laurynas Rimsevicius¹, Marius Miglinas¹, Kestutis Strupas⁵

¹Centre of Nephrology, Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania

²Faculty of Medicine, Vilnius University, Lithuania

³Centre of Radiology and Nuclear Medicine, Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania

⁴Department of Cardiovascular Medicine, Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania

⁵Centre of Abdominal Surgery, Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania

Available Online 6 December 2017.

DOI: 10.1016/j.artres.2017.10.140 How to use a DOI?
Abstract: Vascular calcification (VC) is linked to post-transplant cardiovascular events in the long term. We aimed to evaluate whether pretransplant chest X-ray based aortic arch calcification (AoAC) or pulse wave velocity measurement can better predict post- transplant cardiovascular or cerebrovascular events, and to assess the progression of calcification within 2 years.

Methods: Our single-center observational longitudinal study enrolled 40 kidney transplant recipients (KTR) without previous history of vascular events (no cardiovascular, cerebrovascular events, no peripheral artery disease). Two radiologists evaluated pretransplant and postransplant (after 2 years) AoAC on chest X-ray by using two different AoAC scales: AoAC grade evaluation [1] and AoAC score as suggested by Ogawa et al. in 2009 [2]. Cohen’s kappa coefficient was 0.75. The mismatching results were repeatedly reviewed and resulted in consensus. Carotid-femoral (cfPWV) and carotid-radial pulse wave velocity (crPWV) was measured using applanation tonometry and the PWV ratio (cfPWV/rPWV) was calculated. Patient clinical, biochemical data and cardiovascular/cerebrovascular event rate were monitored within 2 years.

Results: During 2-year follow-up 5 patients experienced cardiovascular events, which were predicted by PWV ratio, but not related to AoAC. In 3 patients, we observed progression of AoAC, in others – AoAC was less evident or remained unchanged in 2-years follow-up. AoAC score [2] could better describe the extent of vascular calcification in KTR.

Conclusions: KTR without previous vascular events have quite low cardiovascular/ cerebrovascular event rate within 2-year follow-up, which are better predicted by pretransplant PWV ratio. AoAC postransplant regression is evident even when using simplified chest X- ray scales.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 20 - C
Pages: 91 - 92
Publication Date: 2017/12/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.140 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Agne Laucyte-Cibulskiene
AU  - Evelina Boreikaite
AU  - Gediminas Aucina
AU  - Migle Gudynaite
AU  - Ilona Rudminiene
AU  - Sigita Anisko
AU  - Loreta Vareikiene
AU  - Liutauras Gumbys
AU  - Nerijus Teresius
AU  - Dileta Valanciene
AU  - Ligita Ryliskyte
AU  - Laurynas Rimsevicius
AU  - Marius Miglinas
AU  - Kestutis Strupas
PY  - 2017
DA  - 2017/12/06
TI  - P109 PROGRESSION OF AORTIC ARCH CALCIFICATION AFTER KIDNEY TRANSPLANT AND ITS IMPORTANCE IN PREDICTING CARDIOVASCULAR RISK: SINGLE-CENTER 2-YEAR FOLLOW-UP STUDY
JO  - Artery Research
SP  - 91
EP  - 92
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.140
DO  - 10.1016/j.artres.2017.10.140
ID  - Laucyte-Cibulskiene2017
ER  -

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