P47 TETRAHYDROBIOPTERIN AND MARKERS OF OXIDATIVE STRESS IN A YOUNG BI-ETHNIC POPULATION: THE AFRICAN-PREDICT STUDY

Hugo Huisman; Carina Mels; Johannes Van Rooyen; Ruan Kruger; Carla Fourie; Lebo Gafane; Wayne Smith; Alta Schutte

doi:10.1016/j.artres.2017.10.075

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Volume 20, Issue C, December 2017, Pages 68 - 68

P47 TETRAHYDROBIOPTERIN AND MARKERS OF OXIDATIVE STRESS IN A YOUNG BI-ETHNIC POPULATION: THE AFRICAN-PREDICT STUDY

Authors

Hugo Huisman¹^{, 2}, Carina Mels³, Johannes Van Rooyen³, Ruan Kruger³, Carla Fourie³, Lebo Gafane³, Wayne Smith³, Alta Schutte³^{, 2}

¹Hypertension in Africa Research Team, North West University, South Africa

²MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, South Africa

³Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa

Available Online 6 December 2017.

DOI: 10.1016/j.artres.2017.10.075 How to use a DOI?
Abstract: Background/Objectives: Tetrahydrobiopterin (BH4) is a cofactor for nitric oxide synthase (NOS). Oxidative stress, reported in black populations (1), may lead to the oxidation of BH4, the uncoupling of eNOS, decreased NO and increased superoxide levels (2,3). We compared BH4 and markers of oxidative stress and their association, between black and white cohorts.

Methods: In the African-PREDICT study, we included black (n = 300) and white (N = 297) participants (aged 20–30 years). We measured blood pressure, and determined serum levels of BH4 and markers of oxidative stress.

Results: Blacks had higher blood pressure (p < 0.001). In blacks the following serum levels were lower: BH4 (p < 0.0001), total antioxidant status (TAS) (p < 0.0001), glutathione peroxidase (GPx), while reactive oxygen species (ROS) (p < 0.03) was higher. In blacks BH4 related positively with GPx in single, partial (adjusted for socio-economic status, sex, age, BMI, GGT and cotinine) and multiple regression (R² = 0.16, β = 0.17, p = 0.02) and glutathione reductase (GR) (R² = 0.16, β = 0.15, p = 0.05). We found a negative correlation between BH4 and GPx (R² = 0.07, β = −0.26, p = 0.0006) in whites.

Conclusions: Higher oxidative stress levels in young blacks (increased ROS, lower TAS and GPx) could explain the low concentrations of BH4, the possible uncoupling of eNOS, resulting in higher blood pressure. The uncoupling of eNOS may explain the production of ROS and peroxinitrite and may be linked to the positive correlation of BH4 with GPx and GR found in blacks, that may lead to early vascular changes.
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Journal: Artery Research
Volume-Issue: 20 - C
Pages: 68 - 68
Publication Date: 2017/12/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.075 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Hugo Huisman
AU  - Carina Mels
AU  - Johannes Van Rooyen
AU  - Ruan Kruger
AU  - Carla Fourie
AU  - Lebo Gafane
AU  - Wayne Smith
AU  - Alta Schutte
PY  - 2017
DA  - 2017/12/06
TI  - P47 TETRAHYDROBIOPTERIN AND MARKERS OF OXIDATIVE STRESS IN A YOUNG BI-ETHNIC POPULATION: THE AFRICAN-PREDICT STUDY
JO  - Artery Research
SP  - 68
EP  - 68
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.075
DO  - 10.1016/j.artres.2017.10.075
ID  - Huisman2017
ER  -

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