4.6 HIPPOCAMPAL CEREBRAL BLOOD FLOW DEPENDS ON SYSTEMIC ENDOTHELIAL FUNCTION IN INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT: THE TRAIN THE BRAIN-MIND THE VESSEL STUDY

DOI

10.1016/j.artres.2017.10.044How to use a DOI?

Abstract

Background: Dementia has been recently viewed as a predominantly vascular disorder. Indeed, reduced brain NO availability causes increased ß-amyloid deposition by several mechanisms, including hypoperfusion.

Purpose: To investigate the relationship between cerebral blood flow in the hippocampal and parahippocampal regions (CBF-hipp and CBF-parahipp), crucial areas for memory and processing of non-verbal/spatial information, and systemic endothelial function in individuals with mild cognitive impairment (MCI), a subclinical condition predisposing to dementia.

Methods: CBF-hipp and CBF-parahipp were evaluated by magnetic resonance imaging (arterial spin labeling, GE HDxt 1.5 T Signa Neuro-optimized System) and systemic endothelial function by flow-mediated dilation (FMD) in the brachial artery.

Results: Complete data about CBF and FMD at enrollment were available for 66 individuals with MCI and 32 without (non-MCI). The two groups were matched for age (75 ± 5 vs 74 ± 5 years, p = 0.22), sex (men 45 vs 50%, p = 0.18) and mean BP (96 ± 10 vs 97 ± 9 mmHg, p = 0.41). FMD was significantly lower in MCI than in non-MCI (2.93 ± 2.18 vs 3.74 ± 2.03%, p = 0.02); CBF-hipp (64.3 ± 9.43 vs 69.5 ± 7.03 ml/100 gr/min, p = 0.002) and CBF-parahipp (66.3 ± 8.02 vs 70.0 ± 8.12 ml/100 gr/min, p = 0.002) were significantly lower in MCI as well. Among MCI, FMD was significantly correlated with CBF-parahipp (r = 0.26, p = 0.03) and CBF-hipp (r = 0.32, p = 0.009). In multiple regression models, including age, sex, mean BP, BMI, brachial artery diameter as confounders, FMD remained an independent determinant of CBF-parahipp (beta = 0.93, r2 = 0.063, p = 0.04) and CBF-hipp (beta = 1.31, r2 = 0.089, p = 0.01). Nor CBF-parahipp (r = −0.13, p = 0.48) neither CBF-hipp (r = 0.05, p = 0.80) were correlated with FMD in non-MCI group.

Conclusions: An independent association between hippocampal and parahippocampal CBF and systemic endothelial function is present in individuals with MCI.

Open Access

This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

TY  - JOUR
AU  - Rosa Maria Bruno
AU  - Lorenza Pratali
AU  - Rosa Sicari
AU  - Francesco Stea
AU  - Nicoletta Berardi
AU  - Gloria Tognoni
AU  - Ubaldo Bonuccelli
AU  - Lorenzo Ghiadoni
AU  - Stefano Taddei
AU  - Danilo Scelfo
AU  - Laura Biagi
AU  - Michela Tosetti
AU  - Lamberto Maffei
AU  - Eugenio Picano
PY  - 2017
DA  - 2017/12/06
TI  - 4.6 HIPPOCAMPAL CEREBRAL BLOOD FLOW DEPENDS ON SYSTEMIC ENDOTHELIAL FUNCTION IN INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT: THE TRAIN THE BRAIN-MIND THE VESSEL STUDY
JO  - Artery Research
SP  - 57
EP  - 58
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.044
DO  - 10.1016/j.artres.2017.10.044
ID  - Bruno2017
ER  -