Artery Research

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Volume 24, Issue C, December 2018, Pages 113 - 114

P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES

Authors
Manoj kumar Choudhary1, 2, 3, Arttu Eräranta1, Antti J. Tikkakoski1, 4, Jenni Koskela1, Elina Hautaniemi1, Mika Kähönen1, 4, Jukka Mustonen1, Ilkka Pörsti1, 5
1Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
2Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
3Department of Internal Medicine, Cardiology unit, Nobel Medical college teaching hospital, Biratnagar, Nepal
4Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
5Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.172How to use a DOI?
Abstract

Background and Aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects.

Methods: Altogether 615 volunteers (19–72 years) without lipid- and BP-lowering medication were recruited. Supine haemodynamics were recorded using continuous radial pulse wave analysis, whole-body impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables.

Results: The mean (SD) characteristics of the subjects were: age 45 (12) years, BMI 27 (4) kg/m2, office BP 141/89 (21/13) mmHg, creatinine 74 (14) μmol/l, total cholesterol 5.2 (1.0), LDL-C 3.1 (0.6), triglycerides 1.2 (0.8), and HDL-C 1.6 (0.4) mmol/l. LDL-C was an independent explanatory factor for aortic systolic and diastolic BP, aortic pulse pressure, augmentation index, pulse wave velocity (PWV), and systemic vascular resistance index (p ≤ 0.013 for all). When central BP was included in the model for PWV, LDL-C was no more an explanatory factor for PWV.

Conclusions: LDL-C is independently associated with BP via systemic vascular resistance and wave reflection. These results suggest that LDL-C may play a role in the pathogenesis of primary hypertension.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
24 - C
Pages
113 - 114
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.172How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Manoj kumar Choudhary
AU  - Arttu Eräranta
AU  - Antti J. Tikkakoski
AU  - Jenni Koskela
AU  - Elina Hautaniemi
AU  - Mika Kähönen
AU  - Jukka Mustonen
AU  - Ilkka Pörsti
PY  - 2018
DA  - 2018/12/04
TI  - P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES
JO  - Artery Research
SP  - 113
EP  - 114
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.172
DO  - 10.1016/j.artres.2018.10.172
ID  - Choudhary2018
ER  -