P68 THE HIDDEN PREDICTOR OF CARDIOVASCULAR OUTCOME

DOI

10.1016/j.artres.2018.10.121How to use a DOI?

Abstract

Background: Hyperuricemia is common in patients with hypertension, diabetes and obesity. Whether it is an independent cardiovascular risk factor (CVRF) or not remains controversial.

Purpose: To determine the prognostic value of uricemia in the setting of acute coronary syndrome (ACS).

Methods: Retrospective single-center study comprising 1187 patients consecutively admitted into a cardiac intensive care unit for ACS, in whom uricemia was measured during hospitalization. Follow-up targeted all-cause mortality (FUM), reinfarction, percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG) and acute heart failure (AHF). Statistical analysis was performed using SPSS, version 25.

Results: Mean age was 68.0 ± 13.3y and 30.4% were female. Prevalence of CVRF was as follows: hypertension, 76.9%; diabetes, 33.4%; dyslipidemia, 65.6%; smoking, 35.5%; chronic kidney disease (CKD), 20.5%. Uricemia was 377 ± 119.2 μmol/l, whereas body mass index (BMI) was 27.8 ± 4.4 kg/m². In-hospital mortality (IHM) was 6%, while median follow-up time was 6y, encompassing the following event rates: FUM, 36.9%; reinfarction, 19.4%; PCI, 21.1%; CABG, 2.3%; AHF, 16.6%. Uricemia was higher in males (p = 0.001) and in patients with hypertension (p < 0.001), diabetes mellitus (p = 0.009) and CKD (p < 0.001) and lower in patients with dyslipidemia (p = 0.031) and smokers (p = 0.03). Age and BMI displayed weak correlation with uricemia. Hyperuricemia had no effect on the burden of reinfaction, PCI and CABG. In a model of logistic regression including the above-mentioned CVRF, hyperuricemia was an independent predictor of IHM (p = 0.009, Hosmer-Lemeshow p = 0.685), FUM (p < 0.001, Hosmer-Lemeshow p = 0.056) and AHF (p = 0.001, Hosmer-Lemeshow p = 0.367).

Conclusion: Hyperuricemia is an independent predictor of mortality and AHF in the setting of ACS.

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TY  - JOUR
AU  - José Sousa
AU  - João Lopes
AU  - Liliana Reis
AU  - Marta Madeira
AU  - Carolina Lourenço
AU  - Lino Gonçalves
PY  - 2018
DA  - 2018/12/04
TI  - P68 THE HIDDEN PREDICTOR OF CARDIOVASCULAR OUTCOME
JO  - Artery Research
SP  - 68
EP  - 68
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.121
DO  - 10.1016/j.artres.2018.10.121
ID  - Sousa2018
ER  -