P50 VALIDATION OF ULTRASOUND DETERMINATION OF LOCAL PULSE WAVE VELOCITY IN THE HUMAN ASCENDING AORTA AGAINST MRI MEASUREMENTS

Madalina Negoita; Charlotte Manisty; Anish Bhuva; Alun Hughes; Kim Parker; Ashraf Khir

doi:10.1016/j.artres.2018.10.103

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Volume 24, Issue C, December 2018, Pages 92 - 93

P50 VALIDATION OF ULTRASOUND DETERMINATION OF LOCAL PULSE WAVE VELOCITY IN THE HUMAN ASCENDING AORTA AGAINST MRI MEASUREMENTS

Authors

Madalina Negoita¹, Charlotte Manisty², Anish Bhuva², Alun Hughes², Kim Parker³, Ashraf Khir¹

¹Brunel Institute of Bioengineering, Brunel University London, UK

²Institute of Cardiovascular Science, University College London, UK

³Department of Bioengineering, Imperial College London, UK

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.103 How to use a DOI?
Abstract: Background: Pulse Wave Velocity (PWV) is a measure of arterial stiffness which predicts cardiovascular risk independently of blood pressure. Local PWV can be measured non-invasively in the ascending aorta of adults by means of Ultrasound (US), using successive recordings of Diameter (D) and the velocity (U) [1].

Aim: To test US measurements of local PWV in the ascending aorta of human adults against MRI measurements of local PWV.

Methods: PWV in the ascending aorta of 8 healthy volunteers (age 22–34 y, 3 females) was measured using a Siemens MAGNETOM Aera 1.5T MRI scanner as per standard protocols with cine and phase contrast imaging (sampling frequency 100 samples/cardiac cycle) and D and U were calculated using validated software [2]. US images were recorded using GE Vivid E95 scanner with a 1.5–4.5 MHz phased array transducer. PLAX was used for diameter recordings and A5CH for velocity. Measurements were recorded for 20 s during a breath-hold. D and U waveforms were extracted from each imaging modality to calculate PWV using the ln(D)U-loops technique [3].

Results: Average results are summarised in Table 1. The mean difference in PWV between MRI and US was 2.8 ± 0.3%.

Conclusions: PWV measured by US shows excellent agreement with MRI in the ascending aorta of adults. Given US availability, this technique offers an easy, affordable and non-invasive means of determining PWV and mechanical properties of the ascending aorta; thus, providing a tool for screening studies.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 92 - 93
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.103 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Madalina Negoita
AU  - Charlotte Manisty
AU  - Anish Bhuva
AU  - Alun Hughes
AU  - Kim Parker
AU  - Ashraf Khir
PY  - 2018
DA  - 2018/12/04
TI  - P50 VALIDATION OF ULTRASOUND DETERMINATION OF LOCAL PULSE WAVE VELOCITY IN THE HUMAN ASCENDING AORTA AGAINST MRI MEASUREMENTS
JO  - Artery Research
SP  - 92
EP  - 93
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.103
DO  - 10.1016/j.artres.2018.10.103
ID  - Negoita2018
ER  -

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