Artery Research

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Volume 24, Issue C, December 2018, Pages 70 - 70

2.4 CENTRAL SYSTOLIC BLOOD PRESSURE PROVIDES ADDITIONAL INFORMATION IN RISK PREDICTION IN HEMODIALYSIS PATIENTS

Authors
Christopher C. Mayer1, Julia Matschkal2, Pantelis A. Sarafidis3, Stefan Hagmair1, Georg Lorenz2, Susanne Angermann2, Matthias C. Braunisch2, Marcus Baumann2, Uwe Heemann2, Christoph Schmaderer2, Siegfried Wassertheurer1
1AIT Austrian Institute of Technology, Center for Health & Bioresources, Vienna, Austria
2Department of Nephrology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany
3Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.027How to use a DOI?
Abstract

Background: Association of Ambulatory Blood Pressure Monitoring (ABPM) with mortality depends on cardiac function in hemodialysis patients. Evidence for the predictive power of central Systolic Pressure (cSBP) is inconclusive. Thus, this study aimed to investigate the additional information of ambulatory cSBP in risk prediction in a cohort of hemodialysis patients.

Methods: Within the ISAR-study cohort, 344 hemodialysis patients underwent 24 h ABPM on the dialysis day. All-cause and cardiovascular mortality served as endpoints. Risk prediction was performed using Cox regression in patients with or without atrial fibrillation (AF) or heart failure (HF) for peripheral (pSBP) and central systolic pressure calibrated with peripheral systolic and diastolic pressure (cSBP1) or peripheral mean and diastolic pressure (cSBP2).

Results: During a mean follow-up of 37.6 (17.5 SD) months, 115 patients died, of whom 47 due to cardiovascular reasons. In patients with AF or HF, a negative association to mortality could be observed, independent of pressure location and calibration (see Table). In patients without AF or HF, these associations were to the opposite directions and cSBP2 was superior to pSBP and cSBP1 for all-cause (pSBP: HR = 1.01, p = 0.30; cSBP1: HR = 1.00, p = 0.77; cSBP2: HR = 1.01, p = 0.06) and cardiovascular (pSBP: HR =1.03, p = 0.02; cSBP1: HR = 1.02, p = 0.06; cSBP2: HR = 1.03, p = 0.003) mortality. This circumstance was confirmed in multivariable analysis combining pSBP and differences between pSBP and cSBP (see Table).

Conclusions: This study provides evidence for the additional information of central systolic blood pressure and its dependency on calibration in risk prediction in hemodialysis patients. Further studies are needed to confirm these findings.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
24 - C
Pages
70 - 70
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.027How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Christopher C. Mayer
AU  - Julia Matschkal
AU  - Pantelis A. Sarafidis
AU  - Stefan Hagmair
AU  - Georg Lorenz
AU  - Susanne Angermann
AU  - Matthias C. Braunisch
AU  - Marcus Baumann
AU  - Uwe Heemann
AU  - Christoph Schmaderer
AU  - Siegfried Wassertheurer
PY  - 2018
DA  - 2018/12/04
TI  - 2.4 CENTRAL SYSTOLIC BLOOD PRESSURE PROVIDES ADDITIONAL INFORMATION IN RISK PREDICTION IN HEMODIALYSIS PATIENTS
JO  - Artery Research
SP  - 70
EP  - 70
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.027
DO  - 10.1016/j.artres.2018.10.027
ID  - Mayer2018
ER  -