Interaction between the microcirculatory network and the systemic arterial pressure

Jose Vilar; Antony W. Kedra; Jean-Jacques Mourad; Jean-Sébastien Silvestre; Bernard I. Lévy

doi:10.1016/j.artres.2010.11.002

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Volume 4, Issue 4, December 2010, Pages 108 - 113

Interaction between the microcirculatory network and the systemic arterial pressure

Authors

Jose Vilar^a, Antony W. Kedra^b, Jean-Jacques Mourad^c, Jean-Sébastien Silvestre^a, Bernard I. Lévy^a^{, b}^{, *}

^aInserm U970, Paris Cardiovascular Research Center, 56, rue Leblanc, 75015 Paris, France

^bDepartment of non-invasive investigations, Physiology, Lariboisière Hospital, 2 rue Ambroise Paré, 75010 Paris, France

^cDept of Internal Medicine & Arterial Hypertension, Avicenne Hospital, Bobigny Cedex, France

^*Corresponding author. Department of non-invasive investigations, Physiology, Lariboisière Hospital, 2 rue Ambroise Paré, 75010 Paris, France. Tel.: +(33)1 49 95 80 87; fax: +(33)1 49 95 86 71. E-mail address: bernard.levy@inserm.fr (B.I. Lévy).

Corresponding Author

Bernard I. Lévy

Available Online 2 December 2010.

DOI: 10.1016/j.artres.2010.11.002 How to use a DOI?
Abstract: The large arterial system and the microcirculatory network are generally studied as separated entities. We aimed to establish a link between the remodelling of microcirculatory and arterial blood pressure.

Experimental: Pre-hypertensive spontaneously hypertensive rats SHRs were maintained under hypoxic (12% O₂) conditions for 8 weeks. The systolic blood pressure was lower by 26% in hypoxic vs. normoxic SHRs. Total peripheral vascular resistance was 30% lower in hypoxic than in normoxic SHRs. At the end of the hypoxic period, capillary density in skeletal muscle was 1.2-fold higher in hypoxic than in normoxic SHRs. Myocardial capillary density and VEGF-A protein contents were also 1.2- and 2.1-fold higher in hypoxic compared to normoxic SHRs. Thus, chronic normobaric hypoxia (1) activates VEGF-A-induced angiogenesis and thereafter (2) prevents or normalizes hypertension in the SHR.

Clinical: Increase in blood pressure (BP) is a hallmark of anti-angiogenic treatments. We used video microscopy to measure dermal capillary densities in the dorsum of the fingers. Measurements were carried out in 18 patients before and after 6-month treatment with bevacizumab. BP was increased compared with baseline from 129 ± 13/75 ± 7 mmHg to 145 ± 17/82 ± 7 mmHg. Compared with the baseline, mean dermal capillary density was significantly lower (75 ± 12 versus 83 ± 13/mm2). Thus, bevacizumab treatment resulted in capillary rarefaction, possibly participating to the rise in BP observed in most patients.

Thus, from experimental and clinical data, we might suggest that activation or blockade of angiogenesis may affect vascular resistance and, subsequently, blood pressure levels.
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Journal: Artery Research
Volume-Issue: 4 - 4
Pages: 108 - 113
Publication Date: 2010/12/02
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2010.11.002 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Jose Vilar
AU  - Antony W. Kedra
AU  - Jean-Jacques Mourad
AU  - Jean-Sébastien Silvestre
AU  - Bernard I. Lévy
PY  - 2010
DA  - 2010/12/02
TI  - Interaction between the microcirculatory network and the systemic arterial pressure
JO  - Artery Research
SP  - 108
EP  - 113
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.11.002
DO  - 10.1016/j.artres.2010.11.002
ID  - Vilar2010
ER  -

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