Artery Research

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Volume 5, Issue 1, March 2011, Pages 1 - 7

Factors influencing hemodynamic and morphological indicators of carotid arteries atherosclerosis in treated hypertensive patients

Authors
Anna Skalska*, Ewa Klimek, Tomasz Grodzicki
Department of Internal Medicine and Gerontology, Faculty of Medicine, Jagiellonian University Medical College, ul. Sniadeckich 10, 31-531 Krakow, Poland
*Corresponding author. Tel.: +48 124248800; fax: +48 124248854. E-mail address: anskal@su.krakow.pl (A. Skalska).
Corresponding Author
Anna Skalska
Received 6 April 2010, Revised 16 July 2010, Accepted 11 August 2010, Available Online 20 September 2010.
DOI
10.1016/j.artres.2010.08.001How to use a DOI?
Keywords
Intima-media thickness; Resistive index; Arterial hypertension; Carotid atherosclerosis
Abstract

Objectives: To evaluate factors influencing resistive index (RI) and intima-media thickness of common carotid artery (IMT-CCA) as indices of arterial atherosclerosis in hypertensive patients.

Methods: 56 treated hypertensive outpatients (mean age 68.9 ± 9.7 years; 31 diabetics) were examined. Fasting blood glucose, cholesterol, and HbA1c concentration and glomerular filtration rate were measured. Systolic (SBP), diastolic blood pressure (DBP) and pulse pressure were estimated during ambulatory blood pressure monitoring. Ultrasonography of the CCA was performed with determination of IMT-CCA and RI.

Results: With diabetes IMT-CCA was significantly (1.025 ± 0.17 vs 0.928 ± 0.18 mm, p = 0.04) and RI not significantly (0.71 ± 0.06 vs 0.68 ± 0.08, p = 0.07) higher. A correlation between HbA1c and RI, IMT-CCA and the age was found. After dividing the whole group into subgroups corresponding to the tertiles of HbA1c levels, mean IMT-CCA values in I and II tertile were significantly lower than in III tertile (p = 0.008 and p = 0.002 respectively), while RI was significantly higher in III tertile than in I tertile (p = 0.03). On multiple regression analysis IMT-CCA was significantly influenced by the age (β = 0.343, p = 0.04), SBP (β = 0.430, p = 0.03) and HbA1c (β = 0.369, p = 0.01), while RI was influenced by SBP (β = 0.696, p = 0.0006), DBP (β = −0.618, p = 0.003) and HbA1c (β = 0.279, p = 0.04).

Conclusion: Patients with hypertension and diabetes mellitus had significantly increased IMT and not significantly higher RI. Concentration of HbA1c, next to the age, SBP and DBP values was independently associated with IMT-CCA and RI – parameters determining indirectly the degree of atherosclerosis of common carotid artery.

Copyright
© 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Next Article In Issue>
Journal
Artery Research
Volume-Issue
5 - 1
Pages
1 - 7
Publication Date
2010/09/20
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.08.001How to use a DOI?
Copyright
© 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Anna Skalska
AU  - Ewa Klimek
AU  - Tomasz Grodzicki
PY  - 2010
DA  - 2010/09/20
TI  - Factors influencing hemodynamic and morphological indicators of carotid arteries atherosclerosis in treated hypertensive patients
JO  - Artery Research
SP  - 1
EP  - 7
VL  - 5
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.08.001
DO  - 10.1016/j.artres.2010.08.001
ID  - Skalska2010
ER  -