5.6 QUANTIFICATION OF BOTH SYSTOLIC AND DIASTOLIC LOCAL ARTERIAL STIFFNESS IMPROVES IDENTIFICATION OF ARTERIAL STIFFENING WITH NORMAL AGING

DOI

10.1016/j.artres.2009.10.164How to use a DOI?

Abstract

Background: We hypothesized that the discrepancy between local and global stiffness is explained by 1) differences in systolic and diastolic stiffness and 2) the co-existence of elastic and muscular arteries in the carotid-femoral trajectory.

Methods: For 1515 subjects (age 35–55, Asklepios cohort) we derived carotid-femoral pulse wave velocity (aoPWV) at diastolic blood pressure and determined carotid and femoral diastolic and systolic distensibility, using the dicrotic notch as cut-off, converted to local PWV using the Bramwell-Hill equation. We evaluated linear regressions of the local measures with brachial systolic blood pressure (SBP), aoPWV and age.

Results (Table): AoPWV increased with SBP at an intermediate rate compared to carotid and femoral diastolic stiffness. Femoral artery PWV increased stronger with aoPWV than carotid PWV (p=0.0006). Interestingly, diastolic and systolic carotid PWV were differentially related to aoPWV, while femoral diastolic and systolic PWV were not. On average, carotid PWV increased faster with age than femoral PWV (p=0.028). Femoral diastolic and systolic PWV did not show a differential increase with age. In contrast, carotid systolic PWV increased twice as fast with age than diastolic PWV.

Conclusion: In middle-aged healthy individuals, global stiffness as expressed by aoPWV is stronger determined by muscular than elastic artery stiffness. Changes in arterial stiffness with age are most strongly reflected in elastic arteries in the systolic pressure range.

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TY  - JOUR
AU  - K. Reesink
AU  - E. Hermeling
AU  - S. Vermeersch
AU  - E. Rietzschel
AU  - M. De Buyzere
AU  - R.S. Reneman
AU  - A.P.G. Hoeks
AU  - P. Segers
PY  - 2009
DA  - 2009/12/03
TI  - 5.6 QUANTIFICATION OF BOTH SYSTOLIC AND DIASTOLIC LOCAL ARTERIAL STIFFNESS IMPROVES IDENTIFICATION OF ARTERIAL STIFFENING WITH NORMAL AGING
JO  - Artery Research
SP  - 156
EP  - 156
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.164
DO  - 10.1016/j.artres.2009.10.164
ID  - Reesink2009
ER  -