Artery Research

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Volume 3, Issue 4, December 2009, Pages 170 - 170

P4.01 EFFECTS OF TOCOLYTICAL MEDICATIONS ON THE PERIPHERAL AND CENTRAL HEMODYNAMICS OF HEALTHY FEMALE VOLUNTEERS

Authors
I.G.M. Fabry2, P. De Paepe1, L. Van Bortel1
1Heymans Institute of Pharmacology, Ghent University, B-9000 Ghent, Belgium
2Drug Research Unit Ghent, Ghent University Hospital, B-9000 Ghent, Belgium
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.042How to use a DOI?
Abstract

Objective: Atosiban and ritodrine are frequently used tocolytics. Only a few studies investigated the hemodynamic effects of atosiban. We therefore aimed to study the central and peripheral hemodynamics of both medications.

Methods: Twenty healthy female volunteers (19–41 yrs) were given atosiban (300 μg/min over 2h) and placebo intravenously (IV) in a random crossover design. Eight of them also received ritodrine IV in escalating doses up to 400μg/min over 2h. The hemodynamics were investigated at steady state using blood pressure (BP) at the brachial artery (BA), pulse wave analysis on the common carotid artery and echocardiography for cardiac output (CO). Statistical analysis was done using Friedman and Wilcoxon tests (value of significance at 0.05).

Results: Effects on atosiban/placebo on N=20 did not differ from N=8.

Parameters Ritodrine (n=8) Atosiban (n=8) Placebo (n=8) p-value$
CI (l/min/m2) 3.15±0.92*# 1.91±0.47 1.75±0.36 0.002
SI (ml/m2) 28.19±6.34*# 32.47±7.07 30.40±4.27 0.325
HR (bpm) 111±20*# 59±10 57±9 0.002
TPRI (mmHg.ml−1.s) 1.53±0.48*# 2.69±0.85 2.93±0.66 0.005
MAP(mmHg) 76±10*# 84±8 82±6 <0.001
AGPP (mmHg) −8.67±12.30 2.29±17.35 4.38±13.67 0.368

CI (cardiac index); SI (stroke index); MAP (mean arterial pressure); TPRI (total peripheral resistance index); HR (heart rate); AGPP (augmentation index at HR 75).

$

Friedman-test;

*

significant vs. atosiban;

#

significant vs. placebo.

Conclusion: Ritodrine has important hemodynamical effects reflected by cardiac stimulation (increase in CI through HR increase) and a decrease in peripheral resistance (TPRI) with a trend for decreasing wave reflections (AGPP). The effect of atosiban on central and peripheral hemodynamics did not differ from placebo.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
3 - 4
Pages
170 - 170
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.042How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - I.G.M. Fabry
AU  - P. De Paepe
AU  - L. Van Bortel
PY  - 2009
DA  - 2009/12/03
TI  - P4.01 EFFECTS OF TOCOLYTICAL MEDICATIONS ON THE PERIPHERAL AND CENTRAL HEMODYNAMICS OF HEALTHY FEMALE VOLUNTEERS
JO  - Artery Research
SP  - 170
EP  - 170
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.042
DO  - 10.1016/j.artres.2009.10.042
ID  - Fabry2009
ER  -