P2.05 CENTRAL HEMODYNAMIC PARAMETERS AND ARTERIAL STIFFNESS IN PAGET’S DISEASE

L. D’Elia; G. Mossetti; C.M. McEniery; D. Rendina; B.J. McDonnell; F. Galletti; P. Strazzullo

doi:10.1016/j.artres.2009.10.021

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Volume 3, Issue 4, December 2009, Pages 178 - 178

P2.05 CENTRAL HEMODYNAMIC PARAMETERS AND ARTERIAL STIFFNESS IN PAGET’S DISEASE

Authors

L. D’Elia¹, G. Mossetti¹, C.M. McEniery², D. Rendina¹, B.J. McDonnell², F. Galletti¹, P. Strazzullo¹

¹Department of Clinical and Experimental Medicine, Federico II University of Naples, Naples, Italy

²Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom

Available Online 3 December 2009.

DOI: 10.1016/j.artres.2009.10.021 How to use a DOI?
Abstract: Background: Paget’s disease of bone (PDB) is a common disorder characterised by increased, disorganised bone turnover in affected areas with overgrowth of immature woven bone. An increased cardiovascular risk has been reported in some studies of PDB, possibly related to arterial wall calcifications. The aim of this study was to evaluate central hemodynamic parameters and arterial stiffness in PDB patients.

Methods: 11 PDB patients and 11 control subjects matched by age, weight, height and cardiovascular risk factors, were enrolled. Anthropometric measures, metabolic profile and information about PDB features (extension, therapy, and genetic alteration of disease) were made available for all subjects. Central hemodynamic parameters and carotid-femoral Pulse Wave Velocity (PWVcf) were assed non-invasively by Sphygmocor.

Results: The PDB and the control group were comparable for age (PBD vs Control: 59±8.0 vs 58±7.2 yrs; M±SD, height: 168±6.7 vs 168±6.0cm and body weight: 78±14 vs 77±12kg). PBD patients presented a significantly higher PWVcf (9.8±1.8 vs 7.7±1.5m/s, p=0.008) and a trend toward higher central PP (48±19 vs 45±10 mmHg, p=0.60). The difference in PWVcf was confirmed after adjustment for age, gender, heart rate and central mean pressure (9.6±0.54 vs 7.18±0.53m/s M±SE; p=0.006).

Conclusions: PDB patients presented evidence of higher arterial stiffness as compared with control subjects. These results support the hypothesis that PDB is a systemic condition associated with increased cardiovascular risk.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 3 - 4
Pages: 178 - 178
Publication Date: 2009/12/03
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2009.10.021 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - L. D’Elia
AU  - G. Mossetti
AU  - C.M. McEniery
AU  - D. Rendina
AU  - B.J. McDonnell
AU  - F. Galletti
AU  - P. Strazzullo
PY  - 2009
DA  - 2009/12/03
TI  - P2.05 CENTRAL HEMODYNAMIC PARAMETERS AND ARTERIAL STIFFNESS IN PAGET’S DISEASE
JO  - Artery Research
SP  - 178
EP  - 178
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.021
DO  - 10.1016/j.artres.2009.10.021
ID  - D’Elia2009
ER  -

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