Gender difference in age-related carotid stiffness: A prospective study in Chinese diabetic patients

Bo Zhao; Yan-Ping Liu; Yifei Zhang; Yuhong Chen; Zhifang Yang; Ying Zhu; Weiwei Zhan

doi:10.1016/j.artres.2012.09.002

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Volume 7, Issue 1, March 2013, Pages 42 - 47

Gender difference in age-related carotid stiffness: A prospective study in Chinese diabetic patients

Authors

Bo Zhao^a, Yan-Ping Liu^a, Yifei Zhang^b^{, c}, Yuhong Chen^b^{, c}, Zhifang Yang^a, Ying Zhu^a, Weiwei Zhan^a^{, *}

^aDepartment of Ultrasonography, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 RuiJin 2nd Road, Shanghai 200025, China

^bShanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 RuiJin 2nd Road, Shanghai 200025, China

^cDivision of Endocrine and Metabolic Diseases of E-Institutes of Shanghai Universities, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 RuiJin 2nd Road, Shanghai 200025, China

^*Corresponding author. Tel.: +86 2164370045-3030. E-mail address: maoweitaoliu@126.com (W. Zhan).

Corresponding Author

Weiwei Zhan

Received 26 July 2012, Revised 24 August 2012, Accepted 3 September 2012, Available Online 1 October 2012.

DOI: 10.1016/j.artres.2012.09.002 How to use a DOI?
Keywords: Type 2 diabetic mellitus; Gender; Age; Carotid stiffness
Abstract: Background: The reason for the particularly increased cardiovascular morbidity and mortality in diabetic women remains unclear. The purpose of our study was to prospectively investigate sex difference in carotid stiffness in elder Chinese patients with type-2 diabetes mellitus (T2DM).

Methods: 109 T2DM patients (mean age at baseline, 58.5 years; 65.1% women) were included in the current study. Carotid stiffness index (CSI) was measured using an ultrasonic phase-locked echo-tracking system at baseline (CSI1) and at follow-up (CSI2). Biochemical measurements and clinical information were also measured.

Results: Mean value of CSI1 and CSI2 were 4.49 ± 1.45 and 7.84 ± 2.37, respectively. CSI1 were similar in both sex (CSI1: 4.49 ± 1.38 vs 4.51 ± 1.59), while CSI2 was higher in women than in men (CSI2: 8.22 ± 2.41 vs 7.13 ± 2.13). After adjusted for other cardiovascular risk factors, the difference in CSI2 between women and men was still significant. Age was the main determinant of CSI1 in both genders. However, correlation between age and CSI2 was only found in women. Women had higher CSI progression (ΔCSI) than men (3.74 ± 2.22 vs 2.62 ± 1.73). Furthermore, being female was an independent risk factor of ΔCSI.

Conclusion: Age was the most important risk factor of carotid stiffness. Nevertheless, after a 4 year follow-up, the impact of ageing on carotid stiffness progression only existed in T2DM women.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 1
Pages: 42 - 47
Publication Date: 2012/10/01
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2012.09.002 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Bo Zhao
AU  - Yan-Ping Liu
AU  - Yifei Zhang
AU  - Yuhong Chen
AU  - Zhifang Yang
AU  - Ying Zhu
AU  - Weiwei Zhan
PY  - 2012
DA  - 2012/10/01
TI  - Gender difference in age-related carotid stiffness: A prospective study in Chinese diabetic patients
JO  - Artery Research
SP  - 42
EP  - 47
VL  - 7
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.002
DO  - 10.1016/j.artres.2012.09.002
ID  - Zhao2012
ER  -

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