Artery Research

<Previous Article In Issue
Next Article In Issue>
Volume 7, Issue 1, March 2013, Pages 48 - 53

The cardio-ankle vascular index predicts chronic kidney disease in Japanese subjects

Authors
Daisuke Maebuchi*, Munehisa Sakamoto, Jun Fuse, Hiroaki Tanaka, Yasuyuki Shiraishi, Makoto Takei, Yumiko Inui, Yuumi Sutoh, Yukinori Ikegami, Yukihiko Momiyama
Department of Cardiology, National Hospital Organization Tokyo Medical Center, Higashigaoka 2-5-1, Meguro-ku, Tokyo 152-8902, Japan
*Corresponding author. Tel.: +81 3 3411 0111; fax: +81 3412 9811. E-mail address: dma4911@yahoo.co.jp (D. Maebuchi).
Corresponding Author
Daisuke Maebuchi
Received 23 August 2012, Revised 18 October 2012, Accepted 26 November 2012, Available Online 20 January 2013.
DOI
10.1016/j.artres.2012.11.004How to use a DOI?
Keywords
Cardio-ankle vascular index; Chronic kidney disease; Predictor; Atherosclerosis
Abstract

Objective: Chronic kidney disease (CKD) is known to be associated with the incidence and mortality of cardiovascular disease. Therefore, the prevention of CKD may improve the mortality of cardiovascular disease. The risk factors of CKD are variable and multifactorial, similar to atherosclerosis. We hypothesized that the index of atherosclerosis predicts future CKD, and investigated the association between the cardio-ankle vascular index (CAVI), the index of arterial stiffness in part of atherosclerosis, and CKD occurrence in non-CKD patients.

Methods: Of the 1000 patients undergoing CAVI in our hospital from 2006 to 2007 without CKD, we followed renal function for 1 or more years in 369 patients. CKD was defined as an estimated glomerular filtration rate of <60 ml/min/1.73 m2.

Results: We divided our study patients into 4 groups according to their CAVI: <8.0 (n = 85), 8.0–9.0 (n = 75), 9.0–10.0 (n = 112), and ≥10.0 (n = 97), respectively. The differences in serum creatinine between baseline and follow-up were 0.09 ± 0.04, 0.11 ± 0.05, 0.17 ± 0.04 and 0.23 ± 0.04, respectively (the P value for the lowest group versus the highest group was 0.04). The age- and sex-adjusted odds ratios (95% confidential interval, P value versus the lowest group) for the occurrence of CKD were 1.13 (0.58–2.20, P = 0.09), 1.58 (0.85–2.94, P = 0.09), and 2.38 (1.23–4.61, P = 0.02). Even after multivariate adjustment, the relationship remained.

Conclusion: CAVI was found to be associated with future renal dysfunction, thus suggesting that a CAVI ≥10 may therefore be a risk factor for CKD in Japanese patients.

Copyright
© 2012 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
7 - 1
Pages
48 - 53
Publication Date
2013/01/20
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.11.004How to use a DOI?
Copyright
© 2012 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Daisuke Maebuchi
AU  - Munehisa Sakamoto
AU  - Jun Fuse
AU  - Hiroaki Tanaka
AU  - Yasuyuki Shiraishi
AU  - Makoto Takei
AU  - Yumiko Inui
AU  - Yuumi Sutoh
AU  - Yukinori Ikegami
AU  - Yukihiko Momiyama
PY  - 2013
DA  - 2013/01/20
TI  - The cardio-ankle vascular index predicts chronic kidney disease in Japanese subjects
JO  - Artery Research
SP  - 48
EP  - 53
VL  - 7
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.11.004
DO  - 10.1016/j.artres.2012.11.004
ID  - Maebuchi2013
ER  -