Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 194 - 200

Augmentation index and arterial stiffness in patients with type 2 diabetes mellitus

Authors
Rachel E.D. Climie, Sonja B. Nikolic, Petr Otahal, Laura J. Keith, James E. Sharman*
Menzies Research Institute Tasmania, University of Tasmania, 17 Liverpool St., Hobart, Tasmania 7000, Australia
*Corresponding author. Tel.: +61 3 6226 4709; fax: +61 3 6226 7755. E-mail address: James.Sharman@menzies.utas.edu.au (J.E. Sharman).
Corresponding Author
James E. Sharman
Received 8 July 2013, Revised 4 September 2013, Accepted 6 September 2013, Available Online 2 October 2013.
DOI
10.1016/j.artres.2013.09.002How to use a DOI?
Keywords
Arterial stiffness; Type 2 diabetes mellitus; Augmentation index
Abstract

Background: Augmentation index (AIx) is regarded as a marker of systemic arterial stiffness. Patients with type 2 diabetes mellitus (T2DM) have increased arterial stiffness, but not AIx, which suggests that mechanisms contributing to AIx in T2DM may differ from healthy individuals and be unrelated to arterial stiffness. The aim of this study was to examine the cardiovascular and clinical determinates of AIx (including arterial stiffness) in patients with T2DM compared with controls.

Methods: Clinical characteristics and haemodynamic variables (including aortic and brachial pulse wave velocity [stiffness], cardiac output, systemic vascular resistance and heart rate) and AIx (by radial tonometry) were recorded in 53 T2DM and 53 matched controls. Correlates of AIx unadjusted for heart rate were assessed by uni- and multi-variable analysis.

Results: Compared with controls, T2DM patients had significantly higher aortic stiffness (7.6 ± 1.6 vs 6.7 ± 1.9 m/s p = 0.016), cardiac output, heart rate, brachial and central BP; lower brachial stiffness and systemic vascular resistance, but no significant difference in AIx (27 ± 9 vs 24 ± 11% p = 0.184). AIx (adjusted or unadjusted) was not significantly related to aortic or brachial stiffness in either group (p > 0.198 all). Independent predictors of AIx in T2DM patients were height and heart rate, whereas in controls, AIx was independently related to height.

Conclusions: Determinants of AIx in patients with T2DM differ from healthy individuals. Moreover, AIx is not significantly related to regional large artery stiffness and should not be regarded as indicative of systemic arterial stiffness.

Copyright
© 2013 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
194 - 200
Publication Date
2013/10/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.09.002How to use a DOI?
Copyright
© 2013 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Rachel E.D. Climie
AU  - Sonja B. Nikolic
AU  - Petr Otahal
AU  - Laura J. Keith
AU  - James E. Sharman
PY  - 2013
DA  - 2013/10/02
TI  - Augmentation index and arterial stiffness in patients with type 2 diabetes mellitus
JO  - Artery Research
SP  - 194
EP  - 200
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.09.002
DO  - 10.1016/j.artres.2013.09.002
ID  - Climie2013
ER  -