Artery Research

Volume 7, Issue 3-4, September 2013, Pages 186 - 193

Aortic stiffness in obese children and adolescents: Comparison of two distance measures of carotid–femoral pulse wave velocity

Authors
Kristian Nebelin Hvidta, b, *, Michael Hecht Olsenc, d, Jens-Christian Holmb, Hans Ibsena
aDivision of Cardiology, Department of Medicine, Copenhagen University Hospital Holbæk, Smedelundsgade 60, 4300 Holbæk, Denmark
bThe Children’s Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbæk, Smedelundsgade 60, 4300 Holbæk, Denmark
cCardiovascular and Metabolic Preventive Clinic, Department of Endocrinology, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark
dHypertension in Africa Research Team (HART), School for Physiology, Nutrition and Consumer Sciences, North-West University, Potchefstroom, South Africa
*Corresponding author. Division of Cardiology, Department of Medicine, Copenhagen University Hospital Holbæk, Smedelundsgade 60, 4300 Holbæk, Denmark. Tel.: +45 59 48 40 73. E-mail addresses: krhv@regionsjaelland.dk (K. Nebelin Hvidt), mho@dadlnet.dk (M.H. Olsen), jhom@regionsjaelland.dk (J.-C. Holm), hib@regionsjaelland.dk (H. Ibsen).
Corresponding Author
Kristian Nebelin Hvidt
Received 11 July 2013, Revised 19 August 2013, Accepted 6 September 2013, Available Online 27 September 2013.
DOI
10.1016/j.artres.2013.09.004How to use a DOI?
Keywords
Adolescence; Aortic stiffness; Augmentation index; Blood pressure; Children; Obesity; Pulse wave velocity
Abstract

Background: The methodology of the gold standard for measuring aortic stiffness, carotid–femoral pulse wave velocity (cfPWV), has been revised in respect to the choice of distance measure. In order to clarify whether increased aortic stiffness is present in obese children and adolescents we investigated cfPWV with the previous (cfPWV-subtracted) and a newly revised methodology (cfPWV-direct).

Methods: In a cross-sectional design, 104 obese patients with age 10–18 years newly referred to the Children’s Obesity Clinic were compared to 50 healthy control individuals. CfPWV was measured non-invasively using the SphygmoCor device, while all distance measures were made with a calliper.

Results: Opposite to the direct distance, the subtracted distance differed across study groups in relation to height (P < 0.006). CfPWV-subtracted was significantly higher for the obese (4.5 m/s CI: 4.4–4.6 vs. 4.3 m/s CI: 4.2–4.5, P = 0.03), whereas cfPWV-direct was significantly lower (4.8 m/s CI: 4.7–4.9 vs. 5.1 m/s CI: 4.9–5.3, P = 0.008). In multiple regression, being obese did not significantly influence cfPWV-subtracted (β = 0.126, CI: −0.04–0.29, NS) whereas it significantly reduced cfPWV-direct (β = −0.34, CI: −0.53–0.15, P < 0.001), when adjusting for age, gender, mean arterial blood pressure and heart rate. Both groups had normal values of cfPWV-subtracted in respect to a European reference material.

Conclusion: The distance measure of cfPWV-direct was associated similarly to height across study groups. Adjusted for main confounders, cfPWV-subtracted was equal whereas cfPWV-direct was reduced in obese compared to normal weighted children and adolescents.

Copyright
© 2013 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
186 - 193
Publication Date
2013/09/27
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.09.004How to use a DOI?
Copyright
© 2013 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Kristian Nebelin Hvidt
AU  - Michael Hecht Olsen
AU  - Jens-Christian Holm
AU  - Hans Ibsen
PY  - 2013
DA  - 2013/09/27
TI  - Aortic stiffness in obese children and adolescents: Comparison of two distance measures of carotid–femoral pulse wave velocity
JO  - Artery Research
SP  - 186
EP  - 193
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.09.004
DO  - 10.1016/j.artres.2013.09.004
ID  - NebelinHvidt2013
ER  -