Aortic stiffness in obese children and adolescents: Comparison of two distance measures of carotid–femoral pulse wave velocity
- DOI
- 10.1016/j.artres.2013.09.004How to use a DOI?
- Keywords
- Adolescence; Aortic stiffness; Augmentation index; Blood pressure; Children; Obesity; Pulse wave velocity
- Abstract
Background: The methodology of the gold standard for measuring aortic stiffness, carotid–femoral pulse wave velocity (cfPWV), has been revised in respect to the choice of distance measure. In order to clarify whether increased aortic stiffness is present in obese children and adolescents we investigated cfPWV with the previous (cfPWV-subtracted) and a newly revised methodology (cfPWV-direct).
Methods: In a cross-sectional design, 104 obese patients with age 10–18 years newly referred to the Children’s Obesity Clinic were compared to 50 healthy control individuals. CfPWV was measured non-invasively using the SphygmoCor device, while all distance measures were made with a calliper.
Results: Opposite to the direct distance, the subtracted distance differed across study groups in relation to height (P < 0.006). CfPWV-subtracted was significantly higher for the obese (4.5 m/s CI: 4.4–4.6 vs. 4.3 m/s CI: 4.2–4.5, P = 0.03), whereas cfPWV-direct was significantly lower (4.8 m/s CI: 4.7–4.9 vs. 5.1 m/s CI: 4.9–5.3, P = 0.008). In multiple regression, being obese did not significantly influence cfPWV-subtracted (β = 0.126, CI: −0.04–0.29, NS) whereas it significantly reduced cfPWV-direct (β = −0.34, CI: −0.53–0.15, P < 0.001), when adjusting for age, gender, mean arterial blood pressure and heart rate. Both groups had normal values of cfPWV-subtracted in respect to a European reference material.
Conclusion: The distance measure of cfPWV-direct was associated similarly to height across study groups. Adjusted for main confounders, cfPWV-subtracted was equal whereas cfPWV-direct was reduced in obese compared to normal weighted children and adolescents.
- Copyright
- © 2013 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
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TY - JOUR AU - Kristian Nebelin Hvidt AU - Michael Hecht Olsen AU - Jens-Christian Holm AU - Hans Ibsen PY - 2013 DA - 2013/09/27 TI - Aortic stiffness in obese children and adolescents: Comparison of two distance measures of carotid–femoral pulse wave velocity JO - Artery Research SP - 186 EP - 193 VL - 7 IS - 3-4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2013.09.004 DO - 10.1016/j.artres.2013.09.004 ID - NebelinHvidt2013 ER -