Variation and variability in carotid-femoral pulse wave velocity

Radhakrishna R. Kallem; Kevin E.C. Meyers; Deirdre L. Sawinski; Raymond R. Townsend

doi:10.1016/j.artres.2013.04.001

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Volume 7, Issue 3-4, September 2013, Pages 230 - 233

Variation and variability in carotid-femoral pulse wave velocity

Authors

Radhakrishna R. Kallem^a^{, *}, Kevin E.C. Meyers^a^{, b}, Deirdre L. Sawinski^a, Raymond R. Townsend^a

^aRenal, Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, 122 Founders, 3400 Spruce Street, Philadelphia, PA 19104, USA

^bDepartment of Nephrology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

^*Corresponding author. Tel.: +1 215 614 0423; fax: +1 215 662 3459. E-mail address: krishna.kallem@uphs.upenn.edu (R.R. Kallem).

Corresponding Author

Radhakrishna R. Kallem

Received 7 December 2012, Revised 22 March 2013, Accepted 8 April 2013, Available Online 1 May 2013.

DOI: 10.1016/j.artres.2013.04.001 How to use a DOI?
Keywords: Pulse wave velocity; Variability; Variation
Abstract: Background: There are very limited data on the day-to-day variability and virtually no data on within-subject measurement variation of carotid-femoral pulse wave velocity (c-fPWV). Therefore, we conducted this study in healthy volunteers to measure both day-to-day variability and day-to-day within-subject measurement variation.

Methods: C-fPWV values were measured in ten adult volunteers resting in supine position for at least 10 min using the SphygmoCor system {AtCor Medical Pty Ltd, West Ryde (Sydney), Australia} on two consecutive days. The data were captured for ten seconds from the right carotid and then right femoral arteries.

Results: The average c-fPWV readings and the between-subject standard deviations (SD) was 7.43 ± 1.9 m/sec for day 1 and 6.93 ± 1.36 m/sec for day 2, which are statistically insignificant with a paired t-test (p = 0.197). However, the Pearson’s correlation showed a coefficient of 0.8 (p value = 0.005). There was a statistically significant difference (p = 0.01) in the within-subject c-fPWV measurement variation, calculated as the mean of the SD comparing day 1 (0.74 ± 0.09 m/sec) and day 2 (0.53 ± 0.07 m/sec). The average MAP was 93.9 ± 2.3 mmHg for day 1 and 90.5 ± 1.7 mmHg for day 2, which were not statistically different (p = 0.1).

Conclusions: The c-fPWV readings were highly reproducible between the two days and the measurement variation in the within-subject c-fPWV is significantly lower on the second day. Our study highlights that day-to-day variability and within-subject measurement variation of c-fPWV, although present is not significant enough to influence the assessment of outcome measures of interventions that alter the arterial stiffness.
Copyright: © 2013 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 230 - 233
Publication Date: 2013/05/01
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.04.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Radhakrishna R. Kallem
AU  - Kevin E.C. Meyers
AU  - Deirdre L. Sawinski
AU  - Raymond R. Townsend
PY  - 2013
DA  - 2013/05/01
TI  - Variation and variability in carotid-femoral pulse wave velocity
JO  - Artery Research
SP  - 230
EP  - 233
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.04.001
DO  - 10.1016/j.artres.2013.04.001
ID  - Kallem2013
ER  -

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