Longitudinal follow-up of ascending versus abdominal aortic aneurysm formation in angiotensin II-infused ApoE−/− mice

Bram Trachet; M. Renard; C. Van der Donckt; S. Deleye; J. Bols; G.R.Y. De Meyer; S. Staelens; B.L. Loeys; P. Segers

doi:10.1016/j.artres.2014.01.001

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Volume 8, Issue 1, March 2014, Pages 16 - 23

Longitudinal follow-up of ascending versus abdominal aortic aneurysm formation in angiotensin II-infused ApoE^−/− mice

Authors

Bram Trachet^a^{, c}^{, *}, M. Renard^d, C. Van der Donckt^e, S. Deleye^b^{, g}, J. Bols^a, G.R.Y. De Meyer^e, S. Staelens^b^{, g}, B.L. Loeys^d^{, f}, P. Segers^a

^aIBiTech – bioMMeda, Ghent University – IMinds, Belgium

^bIBiTech-Medisip, Ghent University-IMinds, Belgium

^cLHTC, EPFL, Lausanne, Switzerland

^dCenter for Medical Genetics, Ghent University, Belgium

^eDivision of Physiopharmacology, Antwerp University, Belgium

^fCentre of Medical Genetics, Antwerp University, Belgium

^gMolecular Imaging Center, Antwerp University, Belgium

^*Corresponding author. IBiTech – bioMMeda, Ghent University – IMinds, De Pintelaan 185B, Ghent, Belgium. E-mail address: bram.trachet@ugent.be (B. Trachet).

Corresponding Author

Bram Trachet

Received 22 November 2013, Accepted 2 January 2014, Available Online 1 February 2014.

DOI: 10.1016/j.artres.2014.01.001 How to use a DOI?
Keywords: Small animal imaging; In vivo micro-CT; High-frequency ultrasound; PET; Angiotensin II; Ascending aortic aneurysm; Abdominal aortic aneurysm; Mice
Abstract: Purpose: To explore new imaging techniques to elucidate some of the differences between both abdominal and ascending aortic aneurysms in the angiotensin II mouse model.

Procedures: Angiotensin II-infusing pumps were implanted in male ApoE^−/− mice (n = 10). In vivo micro-CT, ultrasound and Positron emission tomography (PET) were used to follow up on aneurysm formation.

Results: We observed that the ascending aortic aneurysm gradually increased in size over the course of 49 days, while the abdominal aneurysm appeared much more suddenly in between scan times, or in some cases was not detectable at all on micro-CT. Diastolic backflow was detected from day 7 on in the ascending aorta, but not in the abdominal aorta of animals developing an aneurysm at the respective location. Finally PET 18F-FDG uptake was increased in both the ascending and the abdominal aneurysmatic aorta at day 14, but not at day 7.

Conclusions: Novel imaging techniques should be explored in-depth to come to a better understanding of the difference in morphology and hemodynamics between ascending and abdominal aneurysms in angiotensin II-infused ApoE^−/− mice.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 8 - 1
Pages: 16 - 23
Publication Date: 2014/02/01
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2014.01.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Bram Trachet
AU  - M. Renard
AU  - C. Van der Donckt
AU  - S. Deleye
AU  - J. Bols
AU  - G.R.Y. De Meyer
AU  - S. Staelens
AU  - B.L. Loeys
AU  - P. Segers
PY  - 2014
DA  - 2014/02/01
TI  - Longitudinal follow-up of ascending versus abdominal aortic aneurysm formation in angiotensin II-infused ApoE−/− mice
JO  - Artery Research
SP  - 16
EP  - 23
VL  - 8
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.01.001
DO  - 10.1016/j.artres.2014.01.001
ID  - Trachet2014
ER  -

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