Endothelin-1 system activity in adults with borderline high ldl-cholesterol

Kyle J. Diehl; Brian L. Stauffer; Jared J. Greiner; Christopher A. DeSouza

doi:10.1016/j.artres.2014.03.002

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Volume 8, Issue 3, September 2014, Pages 115 - 118

Endothelin-1 system activity in adults with borderline high ldl-cholesterol

Authors

Kyle J. Diehl^a, Brian L. Stauffer^a^{, b}^{, c}, Jared J. Greiner^a, Christopher A. DeSouza^a^{, b}^{, *}

^aIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA

^bDepartment of Medicine, University of Colorado Denver and the Health Sciences Center, Aurora, CO 80045, USA

^cDenver Health Medical Center, Denver, CO 80204, USA

^*Corresponding author. Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, 354 UCB, Boulder, CO 80309, USA. Tel.: +1 (303) 492 2988; fax: +1 (303) 492 6778. E-mail address: desouzac@colorado.edu (C.A. DeSouza).

Corresponding Author

Christopher A. DeSouza

Received 12 July 2013, Revised 4 February 2014, Accepted 24 March 2014, Available Online 18 April 2014.

DOI: 10.1016/j.artres.2014.03.002 How to use a DOI?
Keywords: Endothelin-1; Vasoconstriction; LDL-cholesterol; Endothelium
Abstract: Background: Modest elevations in plasma low-density lipoprotein (LDL)-cholesterol have been shown to confer a significant increase in cardiovascular risk. Endothelin (ET)-1 is a vasoconstrictor peptide with proatherogenic properties. The experimental aim of this study was to determine whether ET-1 system activity is elevated in adults with borderline high LDL-cholesterol, independent of other cardiometabolic abnormalities.

Methods: Forearm blood flow (FBF; plethysmography) responses to intra-arterial infusion of ET-1, selective ET_A receptor blockade (BQ-123), and non-selective ET_A/B blockade (BQ-123 + BQ-788) were determined in 40 middle-aged and older adults (45–70 years): 20 with optimal/near optimal LDL-cholesterol (<3.4 mmol/L) and 20 with borderline-high LDL-cholesterol (3.4–4.1 mmol/L).

Results: Both groups demonstrated a similar, non-significant (∼10%) reduction in FBF to ET-1. BQ-123 and BQ-123 + 788 elicited a modest, but significant, increase in FBF (∼15–20%) in each group. However, there were no group differences in the FBF responses to either selective ET_A or non-selective ET_A/B receptor antagonism.

Conclusion: Borderline-high LDL-C is not associated with increased ET-1 mediated vasoconstrictor tone. Disrupted ET-1 system activity may not contribute to the increased cardiovascular risk burden with borderline-high LDL-cholesterol.
Open Access: This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue

Journal: Artery Research
Volume-Issue: 8 - 3
Pages: 115 - 118
Publication Date: 2014/04/18
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2014.03.002 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Kyle J. Diehl
AU  - Brian L. Stauffer
AU  - Jared J. Greiner
AU  - Christopher A. DeSouza
PY  - 2014
DA  - 2014/04/18
TI  - Endothelin-1 system activity in adults with borderline high ldl-cholesterol
JO  - Artery Research
SP  - 115
EP  - 118
VL  - 8
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.03.002
DO  - 10.1016/j.artres.2014.03.002
ID  - Diehl2014
ER  -

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