Vitamin E attenuates alcohol-induced aortic wall damage in rats

Leila Norouzi; Alireza Shirpoor; Mohammad-Hasan Khadem Ansari; Behrouz Ilkhanizadeh

doi:10.1016/j.artres.2015.01.003

<Previous Article In Issue

Next Article In Issue>

Volume 10, Issue C, June 2015, Pages 20 - 26

Vitamin E attenuates alcohol-induced aortic wall damage in rats

Authors

Leila Norouzi^a, Alireza Shirpoor^a^{, *}, Mohammad-Hasan Khadem Ansari^b, Behrouz Ilkhanizadeh^c

^aDepartment of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

^bDepartment of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

^cDepartment of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

^*Corresponding author. Tel.: +98 4412770698; fax: +98 4412780801. E-mail addresses: liliphysio@yahoo.com (L. Norouzi), ashirpoor@yahoo.com (A. Shirpoor), khademansari_mh@hotmail.com (M.-H.Khadem Ansari), ilkhanib@gmail.com (B. Ilkhanizadeh).

Corresponding Author

Alireza Shirpoor

Received 17 November 2014, Revised 25 January 2015, Accepted 27 January 2015, Available Online 14 February 2015.

DOI: 10.1016/j.artres.2015.01.003 How to use a DOI?
Keywords: Ethanol; Rat; Oxidative stress; Vascular; Vitamin E
Abstract: Background: In this study the effect of chronic ethanol consumption on vascular wall abnormality via oxidative stress was examined. It was also intended to find out whether vitamin E inhibits the abnormality induced by ethanol in rat vascular wall.

Methods: Twenty-four male wistar rats were divided into three groups, namely, control, ethanol (4.5 g/kgBW intragastrically), and vitamin E treated ethanolic groups(VETE) (300 mg interagastrically).

Results: After 6 weeks treatment of rats, the results revealed that along with a significant increase VSMC proliferation and aorta wall thickness with the increase in the level of Ox-LDL, protein carbonyl, as well as decrease total antioxidant capacity in animal that received ethanol compared to the control group. Significant amelioration of aorta wall changes, along restoration of the elevated level of Ox-LDL, protein carbonyl, lipid profile, and decreased level of total antioxidant capacity to that of controls were found in vitamin E-treated animals.

Conclusions: These findings strongly support the idea that heavy and chronic ethanol consumption initiate atherosclerosis by oxidative stress, and that these effects can be alleviated by vitamin E as an antioxidant.
Open Access: This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

<Previous Article In Issue

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 10 - C
Pages: 20 - 26
Publication Date: 2015/02/14
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.01.003 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Leila Norouzi
AU  - Alireza Shirpoor
AU  - Mohammad-Hasan Khadem Ansari
AU  - Behrouz Ilkhanizadeh
PY  - 2015
DA  - 2015/02/14
TI  - Vitamin E attenuates alcohol-induced aortic wall damage in rats
JO  - Artery Research
SP  - 20
EP  - 26
VL  - 10
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.01.003
DO  - 10.1016/j.artres.2015.01.003
ID  - Norouzi2015
ER  -

download .riscopy to clipboard