Effects of dietary modification with weight loss on central blood pressure during oral glucose tolerance test in overweight/obese men

Toru Yoshikawa; Hiroshi Kumagai; Kanae Myoenzono; Asako Zempo-Miyaki; Takehiko Tsujimoto; Kiyoji Tanaka; Seiji Maeda

doi:10.1016/j.artres.2017.10.199

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Volume 20, Issue C, December 2017, Pages 27 - 34

Effects of dietary modification with weight loss on central blood pressure during oral glucose tolerance test in overweight/obese men

Authors

Toru Yoshikawa^a, Hiroshi Kumagai^a, Kanae Myoenzono^a, Asako Zempo-Miyaki^b, Takehiko Tsujimoto^c, Kiyoji Tanaka^d, Seiji Maeda^d^{, *}

^aGraduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8577, Japan

^bFaculty of Health and Sport Science, Ryutsu Keizai University, 120 Ryugasaki, Ibaraki 301-8555, Japan

^cFaculty of Human Sciences, Shimane University, 1060 Nishikawatsu, Matsue, Shimane 690-8504, Japan

^dFaculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8574, Japan

^*Corresponding author. Fax: +81 29 853 2986. E-mail addresses: yoshikawat@live.jp (T. Yoshikawa), kumazin7@gmail.com (H. Kumagai), kanae.mmmmm@gmail.com (K. Myoenzono), a.miyaki.velma08@gmail.com (A. Zempo-Miyaki), tsujimoto@hmn.shimane-u.ac.jp (T. Tsujimoto), tanaka.kiyoji.ft@u.tsukuba.ac.jp (K. Tanaka), maeda@taiiku.tsukuba.ac.jp (S. Maeda).

Corresponding Author

Seiji Maeda

Received 17 August 2017, Revised 7 October 2017, Accepted 17 October 2017, Available Online 2 November 2017.

DOI: 10.1016/j.artres.2017.10.199 How to use a DOI?
Keywords: Excess weight; Energy restriction; Weight reduction; Glucose challenge; Insulin sensitivity; Aortic pressure
Abstract: Background: Postprandial regulation of central systolic blood pressure (cSBP) is impaired by obesity-related disorders. The present study aimed to examine the effect of hypocaloric diet intervention on cSBP when performing oral glucose tolerance test (OGTT) in overweight/obese men and explore its mechanism.

Methods: Fifteen overweight/obese men (mean ± SD; age, 52 ± 10 years; BMI, 29.1 ± 2.3 kg/m²) completed a 12-week dietary modification program (group lectures and individual counseling conducted 8 times in 12 weeks, 1680 kcal/day). Before and after the program, body mass, daily intakes of total energy and major macronutrients, serum lipid profiles, and homeostasis model assessment for insulin resistance (HOMA-IR) were measured, and plasma glucose, serum insulin, and cSBP (i.e., radial second systolic pressure) were assessed when fasting and at 60 min and 120 min after 75 g oral glucose loading.

Results: The 12-week program led to successful weight loss (−10.1 kg or −12.1%) with significant reductions in the daily intakes of total energy and major macronutrients. Consequently, low-density lipoprotein cholesterol, triglycerides, HOMA-IR (2.1 ± 1.3 to 0.8 ± 0.3, p < 0.01), and glucose and insulin during OGTT were substantially decreased after 12 weeks. The diet program had also resulted in significantly reduced 2-h averaged cSBP during OGTT (111 ± 11 to 103 ± 10 mmHg, p < 0.01). There was a significant correlation between the changes from baseline in both HOMA-IR and 2-h averaged cSBP (r_s = 0.69, p < 0.01).

Conclusions: The current results suggest that the dietary modification–induced improvement in insulin resistance has contributed to a significant reduction in cSBP during OGTT in overweight/obese men.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 20 - C
Pages: 27 - 34
Publication Date: 2017/11/02
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.199 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Toru Yoshikawa
AU  - Hiroshi Kumagai
AU  - Kanae Myoenzono
AU  - Asako Zempo-Miyaki
AU  - Takehiko Tsujimoto
AU  - Kiyoji Tanaka
AU  - Seiji Maeda
PY  - 2017
DA  - 2017/11/02
TI  - Effects of dietary modification with weight loss on central blood pressure during oral glucose tolerance test in overweight/obese men
JO  - Artery Research
SP  - 27
EP  - 34
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.199
DO  - 10.1016/j.artres.2017.10.199
ID  - Yoshikawa2017
ER  -

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