Clinical Hematology International

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Volume 2, Issue 1, March 2020, Pages 32 - 34

Human Herpes Virus-6 Encephalitis Following Autologous Blood and Marrow Transplant

Authors
Jacques Mario Azzi1, *, Doyun Park1, 2, Maher Abdul-Hay1, 2, Kelli Cole2, Frank Cirrone2, Maxim Kreditor1, A. Samer Al-Homsi1, 2
1Department of Medicine, New York University School of Medicine, New York, NY
2Blood and Marrow Transplantation, New York University Medical Center, New York, NY
*Corresponding author. Postal address: 550 1st Avenue, New York, NY 10016. Email: Jacques.Azzi@nyulangone.org
Corresponding Author
Jacques Mario Azzi
Received 3 September 2019, Accepted 21 November 2019, Available Online 28 November 2019.
DOI
10.2991/chi.d.191123.001How to use a DOI?
Keywords
Encephalitis; Bone marrow transplant; Human herpes virus 6; Multiple myeloma
Abstract

Human herpesvirus-6 (HHV-6) is a highly prevalent virus that establishes lifelong latency in human hosts. Symptomatic HHV-6 reactivation rarely occurs in immunocompetent individuals and is best described in immunosuppressed patients such as recipients of bone marrow transplants (BMT). In that setting, HHV-6 reactivation has been associated with fever, rash, pneumonitis, encephalitis, and delayed engraftment. While these complications are well documented in allogeneic transplant, the clinical impact of such reactivation is not well known in autologous BMT. We described a case of HHV-6-associated encephalitis in a previously heavily treated patient with multiple myeloma (MM) following a second autologous BMT, and discuss the need for clinicians to be aware of the potential clinical impact of HHV-6 following autologous BMT in the era of immunomodulatory agents.

Copyright
© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
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Journal
Clinical Hematology International
Volume-Issue
2 - 1
Pages
32 - 34
Publication Date
2019/11/28
ISSN (Online)
2590-0048
DOI
10.2991/chi.d.191123.001How to use a DOI?
Copyright
© 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Jacques Mario Azzi
AU  - Doyun Park
AU  - Maher Abdul-Hay
AU  - Kelli Cole
AU  - Frank Cirrone
AU  - Maxim Kreditor
AU  - A. Samer Al-Homsi
PY  - 2019
DA  - 2019/11/28
TI  - Human Herpes Virus-6 Encephalitis Following Autologous Blood and Marrow Transplant
JO  - Clinical Hematology International
SP  - 32
EP  - 34
VL  - 2
IS  - 1
SN  - 2590-0048
UR  - https://doi.org/10.2991/chi.d.191123.001
DO  - 10.2991/chi.d.191123.001
ID  - Azzi2019
ER  -