Distribution of hemoglobinopathy disorders in Saudi Arabia based on data from the premarital screening and genetic counseling program, 2011–2015

Eman S. Alsaeed; Ghada N. Farhat; Abdullah M. Assiri; Ziad Memish; Elawad M. Ahmed; Mohammad Y. Saeedi; Mishal F. Al-Dossary; Hisham Bashawri

doi:10.1016/j.jegh.2017.12.001

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Volume 7, Issue Supplement 1, March 2018, Pages S41 - S47

Distribution of hemoglobinopathy disorders in Saudi Arabia based on data from the premarital screening and genetic counseling program, 2011–2015

Authors

Eman S. Alsaeed^a^{, *}^,dr.eman.s.alsaeed@gmail.com esalsaeed@moh.gov.sa, Ghada N. Farhat^b, Abdullah M. Assiri^a^{, b}, Ziad Memish^a^{, b}, Elawad M. Ahmed^a, Mohammad Y. Saeedi^a, Mishal F. Al-Dossary^a, Hisham Bashawri^c

^aMinistry of Health, Riyadh, Saudi Arabia

^bHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA

^cMinistry of Health, Makkah, Saudi Arabia

^*Corresponding author.

Corresponding Author

Eman S. Alsaeeddr.eman.s.alsaeed@gmail.com esalsaeed@moh.gov.sa

Received 20 June 2017, Revised 25 October 2017, Accepted 3 December 2017, Available Online 15 December 2017.

DOI: 10.1016/j.jegh.2017.12.001 How to use a DOI?
Keywords: Hemoglobinopathy; Thalassemia; Sickle cell disease; Premarital screening; Saudi Arabia
Abstract: The prevalence rates of β-thalassemia (β-thal) and Sickle Cell Disease (SCD) in Saudi Arabia are considered one of the highest compared to surrounding countries in the Middle East (0.05% and 4.50%, respectively). In this study, Secondary data analysis was obtained from the premarital screening and genetic counseling program (PMSGC), and included 12,30,582 individuals from February 2011 to December 2015. Prevalence rates (per 1000 population) for β-thal and SCD were calculated for carrier status, disease status and their combination. During the 5-year study period, the overall prevalence rate per 1000 population for β-thal was 13.6 (12.9 for the trait and 0.7 for the disease). The prevalence rate for SCD was 49.6 (45.8 for the trait and 3.8 for the disease). Rates for β-thal were found to decrease from 24.2 in 2011, to 12 in 2015. However, SCD rates remained rather constant and ranged from 42.3 in 2011 to 49.8 in 2015. The highest rate for both β-thal and SCD was observed in the Eastern and Southern regions. This result reflects major accomplishment of the PMSGC. This study recommends further improvement in preventive measures in high-risk regions, and enhanced community awareness to provide the highest rate reduction for these disorders.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 7 - Supplement 1
Pages: S41 - S47
Publication Date: 2017/12/15
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2017.12.001 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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ris enw bib

TY  - JOUR
AU  - Eman S. Alsaeed
AU  - Ghada N. Farhat
AU  - Abdullah M. Assiri
AU  - Ziad Memish
AU  - Elawad M. Ahmed
AU  - Mohammad Y. Saeedi
AU  - Mishal F. Al-Dossary
AU  - Hisham Bashawri
PY  - 2017
DA  - 2017/12/15
TI  - Distribution of hemoglobinopathy disorders in Saudi Arabia based on data from the premarital screening and genetic counseling program, 2011–2015
JO  - Journal of Epidemiology and Global Health
SP  - S41
EP  - S47
VL  - 7
IS  - Supplement 1
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2017.12.001
DO  - 10.1016/j.jegh.2017.12.001
ID  - Alsaeed2017
ER  -

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