Efficacy of prophylactic dexamethasone in prevention of postoperative nausea and vomiting

Leila Sekhavat; Robab Davar; Shekoufeh Behdad

doi:10.1016/j.jegh.2014.07.004

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Volume 5, Issue 2, June 2015, Pages 175 - 179

Efficacy of prophylactic dexamethasone in prevention of postoperative nausea and vomiting

Authors

Leila Sekhavat^a^,sekhavat@ssu.ac.ir lsekhavat@yahoo.com, Robab Davar^b^{, *}, Shekoufeh Behdad^c

^aObstetrics & Gynecologist, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

^bResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

^cDepartment of Anesthesia, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

^*Corresponding author. Tel.: +98 3518224001, mobile: +98 9131525637; fax: +98 3518224100.

Corresponding Author

Robab Davar

Received 6 May 2014, Revised 18 July 2014, Accepted 26 July 2014, Available Online 4 September 2014.

DOI: 10.1016/j.jegh.2014.07.004 How to use a DOI?
Keywords: Postoperative; Nausea and vomiting; Dexamethasone; Rescue anti-emetic
Abstract: Objective: Many trials have been conducted with regard to the relative benefits of prophylactic anti-emetic interventions given alone or in combination, yet the results remain unknown. This study reviewed the efficacy of a single prophylactic dose of dexamethasone on postoperative nausea or vomiting (PONV) after abdominal hysterectomy.

Methods: In a prospective study of 100 women undergoing total abdominal hysterectomy (TAH) under general anesthesia, the dexamethasone group (n = 50) received a single dose (8 mg) immediately after the operation, and the saline group (n = 50) received a dose of saline as a placebo, in addition to conventional management. The incidence of nausea, vomiting, the need for an anti-emetic and patient satisfaction with the management of PONV were evaluated during the first 24 postoperative hours.

Results: The overall frequency of nausea during the initial postoperative 24 in the dexamethasone and saline groups were 12% and 18%, respectively, and vomiting was 10% and 16%, respectively (P = 0.001). However, there was a lower need for a rescue anti-emetic drugs in the dexamethasone group (18% vs 24%), but it was not statistically significant (P = 0.06).

Conclusion: The results of this study indicate that a single prophylactic dose of dexamethasone after an operation can reduce postoperative nausea and vomiting.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 5 - 2
Pages: 175 - 179
Publication Date: 2014/09/04
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2014.07.004 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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ris enw bib

TY  - JOUR
AU  - Leila Sekhavat
AU  - Robab Davar
AU  - Shekoufeh Behdad
PY  - 2014
DA  - 2014/09/04
TI  - Efficacy of prophylactic dexamethasone in prevention of postoperative nausea and vomiting
JO  - Journal of Epidemiology and Global Health
SP  - 175
EP  - 179
VL  - 5
IS  - 2
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2014.07.004
DO  - 10.1016/j.jegh.2014.07.004
ID  - Sekhavat2014
ER  -

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