Prevalence and determinants of electrocardiographic abnormalities in African Americans with type 2 diabetes

Matthew B. Sellers; Jasmin Divers; Lingyi Lu; Jianzhao Xu; S. Carrie Smith; Donald W. Bowden; David Herrington; Barry I. Freedman; Elsayed Z. Soliman

doi:10.1016/j.jegh.2014.04.003

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Volume 4, Issue 4, December 2014, Pages 289 - 296

Prevalence and determinants of electrocardiographic abnormalities in African Americans with type 2 diabetes

Authors

Matthew B. Sellers^a, Jasmin Divers^b, Lingyi Lu^b, Jianzhao Xu^c, S. Carrie Smith^c, Donald W. Bowden^c, David Herrington^a, Barry I. Freedman^d, Elsayed Z. Soliman^a^{, e}^{, *}^,esoliman@wakehealth.edu

^aDepartment of Internal Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston-Salem, NC, USA

^bDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA

^cDepartment of Biochemistry, Centers for Diabetes Research and Human Genomics, Wake Forest School of Medicine, Winston-Salem, NC, USA

^dDepartment of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA

^eEpidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA

^*Corresponding author at: Epidemiological Cardiology Research Center (EPICARE), Wake Forest University School of Medicine, Medical Center Blvd., Winston Salem, NC 27157, USA. Tel.: +1 (336) 716 8632; fax: +1 (336) 716 0834.

Corresponding Author

Elsayed Z. Solimanesoliman@wakehealth.edu

Received 9 December 2013, Revised 18 March 2014, Accepted 15 April 2014, Available Online 24 May 2014.

DOI: 10.1016/j.jegh.2014.04.003 How to use a DOI?
Keywords: Electrocardiogram; Diabetes; African Americans; Heart; Hypertension; Cardiovascular disease
Abstract: Background: Electrocardiographic (ECG) abnormalities are independently associated with poor outcomes in the general population. Their prevalence and determinants were assessed in the understudied African American population with type 2 diabetes.

Methods: Standard 12-lead ECGs were digitally recorded in 635 unrelated African American-Diabetes Heart Study (AA-DHS) participants, automatically processed at a central lab, read, and coded using standard Minnesota ECG Classification. Age- and sex-specific prevalence rates of ECG abnormalities were calculated and logistic regression models were fitted to examine cross-sectional associations between participant characteristics and ECG abnormalities.

Results: Participants were 56% women with a mean age of 56 years; 60% had at least one minor or major ECG abnormality [23% ⩾1 major (or major plus minor), and 37% ⩾1 minor (with no major)]. Men had a higher prevalence of ⩾1 minor or major ECG abnormality (66.1% men vs. 55.6% women, p = 0.0089). In univariate analysis, age, past history of cardiovascular disease, diabetes duration, systolic blood pressure, sex and statin use were associated with the presence of any (major or minor) ECG abnormalities. In a multivariate model including variables, female sex (OR [95% CI] 0.79 [0.67, 0.93]), statin use (0.79 [0.67, 0.93]) and diabetes duration (1.03 [1.0, 1.05]) remained statistically significant.

Conclusions: Nearly three out of five African Americans with diabetes had at least one ECG abnormality. Female sex and statin use were significantly associated with lower odds of any ECG abnormality and diabetes duration was significantly associated with higher odds of any ECG abnormality in the multivariable model.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 4 - 4
Pages: 289 - 296
Publication Date: 2014/05/24
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2014.04.003 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Matthew B. Sellers
AU  - Jasmin Divers
AU  - Lingyi Lu
AU  - Jianzhao Xu
AU  - S. Carrie Smith
AU  - Donald W. Bowden
AU  - David Herrington
AU  - Barry I. Freedman
AU  - Elsayed Z. Soliman
PY  - 2014
DA  - 2014/05/24
TI  - Prevalence and determinants of electrocardiographic abnormalities in African Americans with type 2 diabetes
JO  - Journal of Epidemiology and Global Health
SP  - 289
EP  - 296
VL  - 4
IS  - 4
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2014.04.003
DO  - 10.1016/j.jegh.2014.04.003
ID  - Sellers2014
ER  -

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