A prospective, observational, epidemiological evaluation of the aetiology and antimicrobial susceptibility of acute otitis media in Saudi children younger than 5 years of age

Khalid A. Al-Mazrou; Atef M. Shibl; Walid Kandeil; Jean-Yves Pirçon; Cinzia Marano

doi:10.1016/j.jegh.2014.03.002

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Volume 4, Issue 3, September 2014, Pages 231 - 238

A prospective, observational, epidemiological evaluation of the aetiology and antimicrobial susceptibility of acute otitis media in Saudi children younger than 5 years of age

Authors

Khalid A. Al-Mazrou^a^,kalmazrou@gmail.com, Atef M. Shibl^b^{, *}^,amshibl@ksu.edu.sa, Walid Kandeil^c^,walid.x.kandeil@gsk.com, Jean-Yves Pirçon^c^,jean-yves.x.pircon@gsk.com, Cinzia Marano^c^,cinzia.x.marano@gsk.com

^aKing Saud University and King Saud bin Abdulaziz University for Health Sciences, PO Box 86118, Riyadh, Saudi Arabia

^bKing Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia

^cGlaxoSmithKline Vaccines, Avenue Fleming 20, 1300 Wavre, Belgium

^*Corresponding author. Mobile: +966 505 302 775; fax: +966 1 4683813.

Corresponding Author

Atef M. Shiblamshibl@ksu.edu.sa

Received 28 November 2013, Revised 28 February 2014, Accepted 15 March 2014, Available Online 21 April 2014.

DOI: 10.1016/j.jegh.2014.03.002 How to use a DOI?
Keywords: Acute otitis media; Child; Saudi Arabia; Streptococcus pneumoniae; Haemophilus influenzae; Antibiotic resistance
Abstract: Background: Information regarding acute otitis media (AOM) aetiology is important for developing effective vaccines. Here, bacterial aetiology and antimicrobial susceptibility of AOM were determined in young Saudi children.

Methods: Children aged 3–60 months with a new episode of AOM, who had not received antibiotics or had received antibiotics for 48–72 h but remained symptomatic, were enrolled in this prospective, observational, epidemiological study in Riyadh. Middle ear fluid (MEF) samples were collected by tympanocentesis or from spontaneous otorrhea, and tested for the presence of Streptococcus pneumoniae, Haemophilus influenzae, Streptococcus pyogenes and Moraxella catarrhalis. Antimicrobial susceptibility of the identified pathogens was assessed using E-tests.

Results: Between June 2009 and May 2011, 66 children were enrolled. S. pneumoniae was detected in 6 episodes and non-typeable H. influenzae (NTHi) in 8 episodes. Moreover, Staphylococcus aureus, which is an uncommon cause of AOM, was detected in 17 episodes. Pneumococcal serotypes were 7F (n = 2), 23F (n = 2), 19F (n = 1) and 15F (n = 1). Susceptibility to cefotaxime was observed in all pneumococcal and H. influenzae isolates, to cefuroxime in 4/6 pneumococcal and 8/8 H. influenzae isolates, and to penicillin in 5/6 pneumococcal isolates.

Conclusions: S. pneumoniae and NTHi were major bacterial contributors for AOM in Saudi children.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Journal: Journal of Epidemiology and Global Health
Volume-Issue: 4 - 3
Pages: 231 - 238
Publication Date: 2014/04/21
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2014.03.002 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Khalid A. Al-Mazrou
AU  - Atef M. Shibl
AU  - Walid Kandeil
AU  - Jean-Yves Pirçon
AU  - Cinzia Marano
PY  - 2014
DA  - 2014/04/21
TI  - A prospective, observational, epidemiological evaluation of the aetiology and antimicrobial susceptibility of acute otitis media in Saudi children younger than 5 years of age
JO  - Journal of Epidemiology and Global Health
SP  - 231
EP  - 238
VL  - 4
IS  - 3
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2014.03.002
DO  - 10.1016/j.jegh.2014.03.002
ID  - Al-Mazrou2014
ER  -

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